Implant-based breast reconstruction is the most commonly used breast reconstruction procedure in the UK accounting for almost 70% of all immediate breast reconstructions carried out following a mastectomy.
Best-BRA (Is subpectoral or pre-pectoral implant placement Best in immediate BReAst reconstruction?) is a study is of the different implant-based breast reconstruction techniques that are currently performed following a mastectomy. There are two ways in which implants can be placed during implant-based breast reconstruction; the implants can be placed under the chest muscle (a subpectoral implant) or placed on top of the chest muscle (pre-pectoral implant). Both are standard procedures commonly performed across the UK but currently here is currently no good evidence which implant procedure is best for patients.
The Best-BRA study will test whether subpectoral or pre-pectoral implant placement improves women’s satisfaction with the outcome of their reconstruction. However, first we need to find out if such a study is possible before we do a much larger definitive study. The Best-BRA study will randomly divide the women who decide to take part in the study into two equal groups. One group will have a subpectoral implant-based breast reconstruction and the other will have a pre-pectoral implant-based breast reconstruction. We also want to capture how information about the study is given to patients. This will help us understand how research studies are explained to people and if there are any improvements we can make.
Initially, we plan to recruit a small number of hospital sites across the UK to take part to determine whether it is possible to recruit women into the study. Recruitment will start in September 2020 for 12 months and the study will run for 2 years in total.
IRAS Project ID: 279460
Bristol Medical School
University of Bristol
39 Whatley Road
0117 928 7351