
Dr Francesca Spiga
PhD, MSc, BSc
Current positions
Senior Research Associate in Research Synthesis
Bristol Medical School (PHS)
Contact
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Research interests
I am interested in ultradian rhythm of glucocorticoid secretion and the mechanisms underlying dynamic synthesis of glucocorticoid in the adrenal gland. I use a wide range of molecular and cell-signalling techniques to elucidate the dynamic of intra-adrenal processes involved in steroids synthesis and how these dynamics become disrupted in disease such as inflammation and critical illness. I collaborate with mathematicians to develop mathematical models of the intra-adrenal regulatory network using biological data obtained in our studies.
Projects and supervisions
Thesis supervisions
Publications
Recent publications
08/12/2022Reporting and methodological quality of studies that use Mendelian randomisation in UK Biobank
BMJ Evidence-Based Medicine
Socio-Demographic and Psychosocial Predictors of Salivary Cortisol from Older Male Participants in the Speedwell Prospective Cohort Study
Psychoneuroendocrinology
Tools for assessing quality and risk of bias in Mendelian randomization studies
International Journal of Epidemiology
Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis
JAMA - Journal of the American Medical Association
Co-culture of monocytes and zona fasciculata adrenal cells
Molecular and Cellular Endocrinology