
Professor Gianni Angelini
M.D.(Sienna), M.Ch.(Wales), F.R.C.S.(Glas), FETCS
Current positions
BHF Professor of Cardiac Surgery and Director
Bristol Medical School (THS)
Contact
Press and media
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Research interests
The overall goal of my research is to optimise the benefits of cardiac surgery on the heart and patient, while reducing the traumatic effects. Specific areas include:
Adult and Paediatric Cardiac Surgery
Clinical studies and trials to reduce myocardial injury and inflammation during adult cardiac surgery, and reperfusion injury in cyanotic children with congenital heart disease. We also try to reduce the inevitable adverse effects of surgical trauma and cardiopulmonary bypass, e.g. by comparing thoracotomy vs. sternotomy for off-pump coronary coronary artery bypass (OPCAB) surgery, warm vs. cold-blood cardioplegia in on-pump coronary and valve surgery, general anaesthesia with high thoracic epidural vs. general anaesthesia alone, and reduced vs. conventional cross-clamp time in combined coronary and valve surgery.
Angiogenesis and regenerative medicine
Using adult vascular progenitor cells, both for use as cardiovascular biomarkers, and for improving therapies in the clinic.
Atherothrombosis
Carrying out preclinical studies and, subsequently, the first-in-man trials of drug gene-therapy and external stenting to treat vein graft stenosis.
Projects and supervisions
Research projects
BHF Chair - Prof. Angelini
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/04/2017 to 31/03/2022
BHF Chair - Prof. Angelini: BHF CH/1992027/7163 Discretionary
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/04/2017 to 31/03/2023
NIHR BRC Cardiovascular
Principal Investigator
Description
Reducing complications and increasing the chance of survival for patients undergoing cardiac surgery.Managing organisational unit
Bristol Medical School (THS)Dates
01/04/2017 to 31/03/2022
Re-submission of Engineered bioscaffolds for optimal valve replacement
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
03/08/2016 to 02/04/2019
Cortisol2 new
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/05/2015 to 31/01/2017
Thesis supervisions
Publications
Recent publications
01/02/2025Cohort profile: Outcome Monitoring After Cardiac Surgery (OMACS) – a prospective UK cohort study of cardiac surgery patients at the Bristol Heart Institute
BMJ Open
Transcriptomics, proteomics and bioinformatics in Atrial Fibrillation
Bioengineering
A machine learning algorithm-based risk prediction score for in-hospital/30-day mortality after adult cardiac surgery
European Journal of Cardio-Thoracic Surgery
Correction
BMC Research Notes
Corrigendum
Frontiers in Surgery