Research projects currently hosted at CRICBristol

A hugely diverse variety of research projects and clinical trials take place at CRICBristol, with participant groups of all ages that range from healthy volunteers to clinical populations.

Below is a full list of research projects that are currently being hosted by CRICBristol, and their Principal Investigators (PIs).

  • A phase 3 Multicentre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and safety of Aducanumab (BIIB037) in Subjects with Early Alzheimer’s Disease – 221AD301, Dr Elizabeth Coulthard
  • A randomised controlled trial and economic evaluation of a community-based physical activity intervention to prevented mobility-related disability for retired older people: The REACT (REtirement in ACTion) trial, Professor Heidi Johansen-Berg and Dr Jonathan Brooks
  • Bristol bladder trial, Dr Amit Bahl
  • Bristol twin study, Dr Sarah Newell
  • Carotid body removal for the treatment of resistant hypertension, Dr Angus Nightingale
  • Chemoreflex antagonism during lower body negative pressure, Dr Emma Hart
  • Evaluation of a cognitive-motor system for an objective and quantitative measurement of fatigue with functional MRI in patients with Multiple Sclerosis, Dr Jade Thai
  • Evaluation of multi parametric magnetic resonance imaging for characterising lymph node status, peritoneal and liver metastasis in pancreatic cancer, Dr Reyad Abbadi
  • Exploring the effects of a unique eCycling intervention on cardiorespiratory fitness and spatial mobility, Professor Ashley Cooper
  • Food decision making task (FDMT), Professor Jeff Brunstrom
  • Functional and clinical anatomy, Michelle Spear
  • Hippocampal changes in early Alzheimer's disease: A multimodal magnetic resonance study, Professor Risto Kauppinen & Dr Elizabeth Coulthard
  • Identifying the neural subtrates of continued reliance on misinformation, Andrew Gordon
  • Investigating the brain stem responses to pain and blood pressure challenges in healthy volunteers, Dr Jonathan Brooks
  • Long-term neurodevelopmental outcome in newborn infants with neonatal encephalopathys, Professor Marianne Thoresen
  • Lower body negative pressure and pain, Dr Jonathan Brooks
  • MSNA in healthy volunteers with isometric handgrip and thermal nociceptive stimulation, Dr Emma Hart
  • Multi-parametric MRI (including DCE with Gad) of the prostate in cancer patients pre-radiotherapy treatment to identify the dominant prostate tumours for hypothetical dose-painting, Stephen Blake
  • Neuroeconomic mechanisms associated with treatment decision making in multiple sclerosis: a pilot fMRI study, Dr Jade Thai
  • Peripheral chemosensitivity in hypertensive and normotensive humans, Dr Angus Nightingale
  • Phase 3 Efficacy and Safety Study of BIIB037 in subjects with Early Symptomatic Alzheimer’s Disease, Professor Roy Jones
  • Pulsed glucocorticoid replacement therapy for patients with adrenocortical insufficiency secondary to Addison’s disease and congenital adrenal hyperplasia, Stafford Lightman
  • Real-time measurement of blood glucose, diet and activity in type two diabetes (CGM-T2D), Dr Clare England
  • Reducing pathology in Alzheimer“s disease through angiotensin targeting (The RADAR Trial), Dr Patrick Kehoe
  • Relaxometric magnetic resonance imaging study of the human brain, Professor Risto Kauppinen
  • Revealing hippocampal subfield functions by functional magnetic resonance imaging (fMRI), Professor Risto Kauppinen
  • Structural and functional brain network changes following brain damage causing visual field defects, Dr Philip Clatworthy
  • Targeting dopamine to treat impaired memory consolidation in neurodegenerative disease: A double-blind placebo-controlled trialDr Elizabeth Coulthard
  • The exercise pressor reflex in humans with hypertension, Dr Emma Hart
  • TrialNet natural history study of the development of type 1 diabetes, Professor Polly Bingley
  • Understanding asthma phenotypes: Going beyond the atopic/non-atopic paradigm, Professor John Henderson
  • Understanding the neural mechanism of fatigue and memory impairments in MS & CFS/ME, Dr Jade Thai
  • Understanding the neural mechanisms of voice perception and discrimination healthy voices and voices in people with MS and depression: A pilot fMRI study, Dr Jade Thai
  • Xenon and cooling therapy in babies at high risk of brain injury following poor condition at birth: Randomised pilot outcomes study (CoolXenon3 study), Professor Marianne Thoresen


See a list of publications based on previous research projects hosted by CRICBristol.

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