• Veterinary services
• Animal welfare
• Behaviour consultation
• Referring clinical cases
• Residency programme
• Separation related behaviours

Clinical Behaviour Office

Langford-behaviour@bristol.ac.uk

Cleanroom

(TRAC Facility)

• Several class-1000-rated rooms
• Wafer-scale micro and nano fabrication
• Houses process tools for lithography, dry etch, deposition, chemical processing, post processing and characterisation
• Rapid prototyping of a range of devices, including photonic structures, microfluidics, micro-lenses, integrated circuits and MEMS

See Contacts on right hand side of Cleanroom page.

Nuclear Magnetic Resonance Facility

(TRAC Facility)

Biological NMR:

• High-field Nuclear Magnetic Resonance spectrometry
• Protein and small molecule structure analysis
• Protein-ligand binding studies

Chemical NMR:

• Solution state Nuclear Magnetic Resonance spectrometry of small molecules
• Multinuclear and diffusion NMR
• Molecular structure and mixture analysis

Matt Crump (Biological NMR)

Matt.Crump@bristol.ac.uk

Craig Butts (Chemical NMR)

Craig.Butts@bristol.ac.uk

Chemical:

• Bruker 700 MHz spectrometer with 1.7 mm cryoprobe
• Bruker Avance 400
• Bruker Avance 300
• Bruker 500 MR NMR Spectromer  with 13C cryoprobe
• JEOL Eclipse 300 NMR Spectrometer
• JEOL ECS 400 NMR Spectrometer
• JEOL ECS 300 NMR Spectrometer
• Varian 400 MR NMR Spectrometer
• Varian 500 VNMRS NMR Spectrometer
• Varian INOVA 600 MHz NMR Spectrometer
• Varian VNMRS 600 spectrometer with cryoprobe 

• DNA and RNA sequencing, analysis and quality assessment
• Microarray expression analysis
• High-throughput Genotyping
• Real-time quantitative PCR
• Capillary sequencing and genotyping
• Bioinformatic support

Genomics Facility

genomics-facility@bristol.ac.uk

For a full and up to date equipment list, visit the Bristol Genomics Facility page and explore the 'Our services' menu on the right.

Bristol NanoESCA Facility

(TRAC Facility)

• High-resolution surface chemical state analysis
• Photoemission electron microscopy (PEEM)
• Multichannel XPS
• SPA-LEED
• Imaging and spectroscopy/diffraction modes
• Low energy electron diffraction
• Specialist light sources
• In situ annealing and sputtering
• UHV suitcase
• Materials analysis

Bristol NanoESCA Facility

info-nanoesca@bristol.ac.uk

• Purpose built low noise and ultra-low noise labs achieving vibration levels lower than the lowest recognised criteria (Vibration Criteria G – VC-G) plus protection from electrical noise
• Soundproof chamber
• Class 1000 clean room
• Technically supported
• Sample preparation laboratories

 Contacts and how to find us

Electron and scanning probe microscopy

(TRAC Facility)

• Scanning electron microscopy (SEM)
• Transmission electron microscopy (TEM)
• Atomic force microscopy (AFM)
• Nanoscale imaging and analysis
• Full technical and training support
• Chemical imaging and analysis

Sean Davis  

S.A.Davis@bristol.ac.uk 

• JEOL 200 Kv Field Emission Gun TEM 2100F with STEM
• Electron diffraction
• Gatan digital camera
• Oxford Instruments Energy Dispersive X-ray analysis system (80mm2 SSD; Aztec)
• Gatan Cryo holder and heating holder
• JEOL 120 Kv 1400 TEM with Gatan digital camera
• JEOL 120 Kv 1200 Mk2 TEM with SIS digital camera
• JEOL SEM IT300 LV with Oxford Instruments Energy Dispersive X-ray analysis system (80mm2 SSD; Aztec)
• JEOL Field Emission Gun SEM 6330 with Gatan Cathodoluminescence and Oxford Instruments Energy Dispersive X-ray analysis
• Bruker Multimode 3 with Quadrexed Nanoscope 3D controller
• Bruker Multimode 8 PeakForce QNM allowing conductivity and quantitative material property (including modulus, adhesion, deformation, and dissipation) mapping
• Vacuum coating (C and Pt/Pd, Au)
• Ultramicrotomy
• Critical point drying and freeze-drying

Mass Spectrometry

(TRAC Facility)

• Mass spectrometry
• Chemical mass spectrometry
• Material analysis
• HPLC-MS/UPLC-MS
• LC-MSn
• Nano-LC-MS
• IMS-MS
• Accurate mass, EI, CI, ESI, nanospray and Maldi MS

Paul Gates

Paul.Gates@bristol.ac.uk

• Thermo Scientific Orbitrap Elite High resolution (MSn) mass spectrometer with UPLC/HPLC.
• Waters Synapt G2S IMS-TOF mass spectrometer with Nanomate source.
• Bruker Daltonics UltrafleXtreme 2 High resolution MALDI-TOF/TOF mass spectrometer.
• Bruker Daltonics micrOTOF Focus II High resolution TOF mass spectrometer.
• Applied Biosystems 4700 Proteomics MALDI-TOF/TOF mass spectrometer.
• Bruker Daltonics Esquire 6000 Ion-trap mass spectrometer with HPLC.
• VG Autospec 3 sector (double focussing) mass spectrometer 

Electron Microbeam Laboratories

(TRAC Facility)

• Nanoscale imaging and quantitative compositional analysis
• Materials analysis
• Training in Electron Microscopy and X-ray microanalysis methods
• Spectroscopy

Stuart Kearns

Stuart.Kearns@bristol.ac.uk

• Hitachi S-3500N variable pressure microscope equipped with Thermo Noran energy dispersive spectrometer (EDS x-ray detector)
• Environmental secondary electron detector (ESED) and BSE detector, JEOL JXA8530F Hyperprobe (EPMA)
• Field Emission Gun electron source
• Cameca SX100 microprobe
• 5 wavelength dispersive spectrometers
• Energy dispersive spectrometer

• Histochemistry
• Fresh and fixed, frozen sectioning
• Fixation and staining
• Wax processing
• Immunocytochemistry
• Immunofluoresent staining
• Image capture
• Consultancy
• Clinical studies

See Contacts at bottom of Histology Services page.

• Cryostat x4.
• Sliding microtome with peltier cooling x1.
• Rotary microtomes x4.
• Thermo Excelsior processor.
• Medite TP15 processor.
• Medite embedding centre.
• Slide printer.
• Cassette printer.
• Leica DM750 microscope with integral digital camera.
• Motik SMZ-168 dissecting microscope with integral digital camera with bespoke thermal stage for orientation of wax embedded tissue.
• Vast range of stains.
• 10L Liquid nitrogen dewar.
• Virtual Microscope.
• Shandon knife sharpener.

• Inductively Coupled Plasma – Optical Emission Spectrometry
• Trace analysis of aqueous solutions
• Metal, CA, Na and K ion detection
• Soil leachate analysis
• Spectroscopy

See Contact at bottom of Aqueous Geochemistry page.

• Illumina microarray processing and expertise
• Methylation analysis
• DNA analysis
• SNP genotyping arrays
• Bioinformatics support
• Dedicated Biobank storage facility

bbl-arrays@bristol.ac.uk

Interface Analysis Centre - Techniques & Analytical Methods

(TRAC Facility)

• Materials analysis
• Focused Ion Beam (FIB)
• Electron and Optical microscopy
• Spectroscopy
• X-ray diffraction
• Thermogravimetric Calorimetry (DSC)
• Imaging
• High-Speed Atomic Force Microscopy

See Contacts on right hand side of IAC techniques & analytical methods page.

For a full and up to date equipment list, see the IAC's Techniques & analytical methods page.

• Veterinary services
• Animal welfare
• Diagnostic Laboratories
• Farm Animal Practice
• Small Animal Hospital
• Stables Equine Practice

Langford Vets Contact Page

• State of the art diagnostic imaging facilities including X-rays, ultrasound scans, Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) scanning.
• Quantitative real-time PCR
• TB testing
• Laboratory and post-mortem facilities

• Clinical studies
• Cell culture
• Cell Line Authentication
• Repository Production
• Over Passaging of Cells
• Cross Contamination
• Infection Identification and Control
• Quarantine

Sue Christie

sue.christie@bristol.ac.uk

• Protein Separation
• Protein identification
• Quantitative Proteomics (SILAC, TMT)
• Phosphoproteomics
• Serum Proteomics
• LC-MS service

See Proteomics Facility Contacts Page

• Orbitrap Fusion Tribrid Mass Spectrometer with up-stream Ultimate 3000 nano-LC system (Thermo Scientific)
• LTQ-Orbitrap Velos Mass Spectrometer with up-stream Ultimate 3000 nano-LC system (Thermo Scientific)
• DigestPro automated digestion unit (Intavis Ltd.)
• 2 x Ultimate 3000 stand alone LC systems for peptide fractionation (Thermo Scientific)
• GE Healthcare IPGphor3 Isoelectric Focussing Units
• GE Healthcare Ettan DALT Twelve and Six Separation Units
• GE Healthcare DALT Twelve Gel caster
• GE Healthcare Typhoon 9400 Variable Mode Imager

Faculty of Science  Workshops

(Service)

• Mechanical, glass and electrical engineering
• Design, prototyping, manufacture, modification, repair and testing
• High and ultra-low vacuum
• Cryogenics

See Faculty of Science Workshops Contacts Page

• Water jet cutting
• CNC milling
• Manual milling and turning
• Comprehensive fabrication facilities including laser, MIG/TIG and MMA welding
• Traditional scientific glass blowing and manufacturing equipment
• Glass diamond saws and grinders
• Laser cutter
• 3D printer

• Latest-state-of-the-art light/optical and electron microscopy
• Cell and life sciences imaging for biological and biomedical research

See Wolfson Bioimaging Facility Contacts Page

• Leica SP5 confocal imaging systems (3, incl 1 with resonant scanner and hybrid detectors)
• 2 Leica SP8 confocal systems (with resonant scanner and hybrid detectors)
• Leica SPE confocal system
• Ultraview Spinning Disk
• Widefield imaging systems (6, various specs)
• Leica TIRF microscope
• Leica SP8 Multiphoton
• Leica SP8 Fluorescence lifetime imaging microscope
• Leica SP8 STED (super-resolution)
• Leica SP8 fluorescence correlation spectroscopy
• Perkin Elmer Opera LX high content screening system
• Essen IncuCyte high throughput live cell imaging system
• Tecnai 12 -FEI 120kV BioTwin Transmission Electron Microscope (TEM)
• Tecnai 20 -FEI 200kV LaB6 Twin Lens Transmission Electron Microscope (TEM) including HAADF-STEM detector and cryo capabilities
• Quanta 400FEI FEG Scanning Electron Microscope (SEM) with cryo attachment
• Vitrobot
• High Pressure Freezer, Leica EMPACT2 + RTS
• Cryo-ultramicrotome
• Ultramicrotome
• Photo-oxidation light microscope (Correlative Microscopy)
• Cryo fluorescence Light Microscope (Correlative Microscopy) 

• Advanced technology and expert support for high resolution electron cryo-microscopy.

See 'Access the facility' page to make an enquiry

• High speed digital benchtop cytometers and a state of the art Fluorescence Activated Cell Sorter (FASC) 

See details on the right of the Flow cytometry page

• A custom-built facility that supports microbial cell culture and protein production.

See the BioSuite Facility page to make an enquiry

• CRIC Bristol provides key facilities for clinicians and academics to deliver cutting-edge research and improved patient care.

X-ray crystallography

(TRAC Facility)

• Single crystal X-ray structure determination/analysis (90-400K)
• Absolute structure determination
• Routine powder X-ray diffraction measurements
• Variable temperature powder X-ray diffraction measurements (16-300K)

Hazel Sparkes

hazel.sparkes@bristol.ac.uk

• Bruker D8 Advance Powder Diffractometer
• Bruker Microstar Rotating Anode Copper Diffractometer
• Bruker Kappa Apex II Molybdenum sealed tube single crystal diffractometer

X-ray Tomography (XTM) Facility

(TRAC Facility)

• Micro-CT X-ray imaging
• 3D imaging and analysis
• Imaging suite workstations and software for 3D visualisation and analysis

See contact on right hand side of X-ray Tomography (XTM) Facility page, under 'Quotes, booking and information'.

• Nikon XT H 225 ST CT scanner
• Imaging lab with high spec workstations and software for 3D visualisation and analysis of tomographic datasets

• Engineering
• Soil-structure interaction
• Seismic qualification
• Vibration testing

• 6m x 4m 2g biaxial seismic shaking table with 50 tonne payload capacity
• 1.2m x 1.2m 6-degree-of-freedom 8g shaking table with 500kg payload capacity
• 6m x 5m x 4m deep soil test pit with surrounding strong floor for bespoke placement of multiple actuators up to 1Mn

• Engineering
• Seismic qualification
• Vibration testing
• Structural testing

• 3x3m 6-degree-of-freedom 5g shaking table with 15 tonne payload capacity
• Strong floor and reaction walls and hydraulic actuator portfolio for bespoke test set-ups

• Engineering
• Aeroacoustics
• Aerodynamics
• Propeller testing

• 7x5ft Closed Test Section Wind Tunnel with speeds of up to 60m/s.
• Low Turbulence Wind Tunnel designed for faster speed testing up to 100m/s, equipped with particle image velocimetry equipment (PIV) and a test section of approximately 0.8m x 0.6m.
• Aero acoustic Wind Tunnel, an anechoic chamber approximately 7m x 4.5m x 3.5m and fully anechoic down to 160Hz, this has a velocity range of 8m/s to 12m/s.
• The pressure-neutral acoustic wind tunnel is a closed-loop, open section wind tunnel. With a velocity range of 5m/s to 35m/s.
• Currently being built Boundary Layer Wind Tunnel, with a test section which will span over 18m in length and capable of creating a boundary layer of 25cm thick.
• Jet noise facility allows a flow of compressed air of between Mach 0.1 and 1.4.

Bristol Radiocarbon Mass Spectrometry Facility (BRAMS)

(TRAC Facility)

• The MICADAS accelerator mass spectrometer is a high-precision and compact instrument that is capable of measuring radiocarbon dates on even the tiniest of samples.
• It is capable of analysing samples as both graphite targets and CO₂ gas, with applications ranging from archaeology through to palaeoclimatology, past and present environmental studies, and geosciences.
  

Tim Knowles

tim.knowles@bristol.ac.uk

Fotis Sgouridis

f.sgouridis@bristol.ac.uk