Intercalated BSc in Health Sciences: example research projects 2014/15

Examples of research dissertation projects offered in 2014/15
TitleSupervisors

What is the association between autoantibodies to epidermal transglutaminase and autoantibodies to tissue transglutaminase in patients with and individuals at increased risk of coeliac disease related autoimmunity?

Dr Alistair Williams & Dr Karen Elvers

Identification of the metabolic pathways involved in hyperglycaemia-induced epithelial to mesenchymal transition (EMT).

Dr Claire Perks & Prof Jeff Holly

The patterns of expression of novel osteoarthritis markers in human articular cartilage.

Dr Mo Sharif & Dr Yunhe Xu

Does cAMP regulate VSMC proliferation by inhibiting the Hippo-signalling pathway?  Dr Mark Bond
The role of extracellular matrix rigidity in the regulation of vascular smooth muscle cell proliferation.  Dr Mark Bond
Using genetically-modified human mesenchymal stem cells (HMSCs) to treat coronary artery vein graft disease.

Prof Andrew Newby & Dr Steven White

Tissue engineering vascular grafts for congenital heart defects corrective surgery using perinatal stem cells.

Dr Mohamed Ghorbel & Prof Massimo Caputo

Cyclic AMP and excitation-contraction coupling in isolated rat cardiomyocytes. Prof Saadeh Suleiman & Dr Igor Khaliulin
Extracellular microRNAs as predictive biomarkers of acute kidney injury after coronary artery-by-pass graft surgery (CABG). Prof C Emanueli & Prof GD Angelini & Dr C Rogers
The effects of glomerular endothelial glycocalyx disruption on glomerular function in mice. Dr Becky Foster
Shear-stress regulated cell-cell communication via microRNA in the renal glomerulus in diabetes. Dr Simon Satchell & Dr Becky Foster & Dr Gavin Welsh
Role of Leptin in the pathogenesis of albuminuria in diabetes. Dr Simon Satchell & Dr Gavin Welsh
Role of INF2 mutations in the pathogenesis of Focal and segmental glomerulosclerosis (FSGS). Dr Gavin Welsh
Exploring the molecular biology of Diabetic Kidney disease. Prof Richard Coward & Dr Gavin Welsh
Regulatable gene therapy in spinal cord injury. Mr Darren Carwardine & Dr Liang-Fong Wong
Understanding the role of stress-induced neurodegeneration at the synapse. Prof Kei Cho & Dr Daniel Whitcomb

Investigation of the IL-33/ST2 signalling in a mouse in vivo model of myocardial infarction and peripheral limb ischemia.

Prof C. Emanueli & Dr M. Besnier
Understanding osteoarthritis: how does weight-bearing influence the development of osteoarthritis in extreme high bone mass. Dr Celia Gregson & Dr Sarah Hardcastle
The association between osteoporosis and back pain in a cohort of womenaged 65-80 from primary care. Dr Emma Clark
Knowledge of osteoporosis in a population of women aged 65-80 from primary care. Dr Emma Clark
Systematic review of the impact of uncorrected adolescent idiopathic scoliosis, plus critique of the literature.  Dr Emma Clark
Role of social isolation on pain and function outcomes after lower limb joint replacement.   Dr Erik Lenguerrand
Medical Innovations. Prof Chris Melhuish & Prof Andy Levy & Prof Rob Tulloh

Hippocampal changes in Behavioural variant Frontotemporal Dementia: A multimodal Magnetic Resonance Study.

Dr C.Pennington & Dr E.Coulthard
Neural Mechanisms underlying fatigue: a voxel-based morphometric MRI study of chronic fatigue syndrome (CFS/ME). Dr Jade Thai
Neural correlates of fatigue in Multiple sclerosis: A MRI study. Dr Jade Thai
Correlations between regional brain atrophy and cognition in chronic obstructive pulmonary disease. Dr James Dodd & Dr Catherine Pennington
Surgical treatment of pituitary tumours – what is the best approach? Dr Denize Atan

Developing a multi-component prehabilitation intervention to improve outcomes for people undergoing surgery for cancer.

Dr Maria Pufulete & Dr Sanjoy Shah
Urinary and blood biomarkers for predicting acute kidney injury following cardiac surgery: a systematic review. Prof Gianni Angelini & Dr Chris Rogers & Prof Costanza Emanueli

Intercalated BSc in Clinical Sciences

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