Postgraduate research projects: Translational Health Sciences

Project titleSupervisorsResearch group

Fluid Dynamics in the human glomerulus: the formation of ultrafiltrate and possible counter-current enhancement of solute diffusion [or glomerular plumbing goes crazy!].

Dr Chris NealDr Alberto Gambaruto  Bristol Renal

Getting BADASS with the role of the renin angiotensin system in disease

Prof Patrick Kehoe, Prof Dek Woolfson, Dr Scott Miners Institute of Clinical Neuroscience

Development of an isolated glomerular albumin permeability assay to high throughput for drug screening in human glomerular disease

Dr Rebecca Foster, Prof Simon SatchellProf Bruce Drinkwater Bristol Renal

Endothelial glycocalyx as a novel therapeutic target in myocardial and renal ischemia reperfusion injuries

Prof Simon SatchellProf Saadeh SuleimanDr Raina Ramnath Bristol Renal

Hyaluronic acid plays a key role in protecting against diabetic kidney disease

Dr Rebecca FosterProf Simon Satchell Bristol Renal

Identification, characterisation and functional assessment of long non-coding RNA regulation of foam cell macrophage formation during atherosclerosis and aneurysm progression

Dr J JohnsonDr K Di Gregoli Bristol CardioVascular

Investigating intracellular signalling mechanisms in the hippocampus: implications in memory formation and disease

Prof James UneyDr Liang-Fong Wong

Bristol Neuroscience

Investigating the timing and causes of vascular dysfunction in Alzheimer’s disease

Dr Scott MinersProf S Love 

Institute of Clinical Neuroscience

Mechanistic investigation of cardiac complications of COVID-19

Prof Paolo MadedduDr Elisa Avolio  Bristol CardioVascular
The role cardiac sympathetic stimulation in protecting the failing heart during cardioplegic arrest Prof Saadeh SuleimanDr Martin Lewis, Prof Massimo Caputo Bristol CardioVascular
 A study of the natural history of joint hypermobility using a population-based birth cohort Dr Emma ClarkProf Andy Judge, Prof Shea Palmer
Musculoskeletal 

Studies of brain renin angiotensin system changes in Parkinson’s disease to find new treatments

Prof Patrick KehoeDr Scott Miners Institute of Clinical Neuroscience

Investigating associations between the brain renin angiotensin system and Traumatic Brain Injury

Prof Patrick KehoeDr Scott MinersDr Kanch Sharma Institute of Clinical Neuroscience

Investigating the conflicting roles of the renin angiotensin system in Alzheimer’s disease

Prof Patrick KehoeDr Scott Miners, Institute of Clinical Neuroscience

Does the brain renin angiotensin system influence the occurrence of depression in Alzheimer’s disease?

Prof Patrick KehoeDr Scott MinersDr Lindsey Sinclair Institute of Clinical Neuroscience

Investigating the role of the renin angiotensin system in COVID19 patients

Prof Patrick KehoeDr Scott Miners, Dr David Arnold Institute of Clinical Neuroscience

Investigation of mechanistic links between metabolic stress, inflammation, and apoptosis in osteoarthritis

Mo Sharif, Dr Mike Whitehouse

Musculoskeletal 

Discovery and validation of clinically useful biomarkers for osteoarthritis

Mo SharifProf Ashley Blom

Musculoskeletal 

Does ultrasound-mediated neuromodulation restore cellular function in Alzheimer’s disease?

Dr Daniel Whitcomb, Prof Bruce Drinkwater 

Institute of Clinical Neuroscience

Evaluation of novel therapies for human coronary artery bypass graft disease

Prof Sarah GeorgeDr Jason Johnson

Bristol CardioVascular

The effect of age on arterial remodelling: relevance to atherosclerotic plaque progression and aneurysm formation

Prof Sarah GeorgeDr Jason Johnson

Bristol CardioVascular
Targeting acute inflammation to reduce coronary artery vein graft failure using bioengineering Prof Sarah GeorgeDr Jason Johnson Bristol CardioVascular
Investigating the role of the regulatory renin-angiotensin system in protecting against synaptic dysfunction in Alzheimer’s disease Dr Scott MinersDr Daniel Whitcomb Institute of Clinical Neuroscience
Understanding the mechanisms of human labour to improve management of preterm labour and induction of labour Dr Kate BirchenallDr Gavin Welsh Bristol Renal

The role of GRP78 in the intrinsic actions of IGFBPs -2 and -3 in breast cancer

Dr Claire PerksDr Kalina BiernackaProf Jeff Holly IGFs and Metabolic Endocrinology Group
α-synuclein and microRNA function in human dopamine neurons Dr Liang-Fong Wong, Dr Oscar Cordero-Llana  Bristol Neuroscience
Characterising the stress response in human neurons derived from induced pluripotent stem cells Prof James UneyDr Oscar Cordero-Llana  Bristol Neuroscience

Obesity, type 2 diabetes and the thrifty genotype hypothesis

Prof David Murphy, Prof Abdulaziz Alagaili, Kate Ellacott  Bristol Neuroscience
Bio-fabricating constructs suitable for pulmonary valve replacement therapy in paediatric patients with congenital heart defect Dr M Ghorbel Bristol CardioVascular
Exploring 3D bio-printing technology for fabrication of cardiovascular tissue Dr M Ghorbel Bristol CardioVascular
A potential therapeutic role for insulin-like growth factor-I (IGF-I) in Alzheimer’s Disease Dr Claire Perks, Prof Patrick KehoeDr Rachel Barker, Dr Shelley-Allen IGFs and Metabolic Endocrinology Group
Understanding and curing genetic kidney disease Dr Gavin WelshProf Moin Saleem Bristol Renal
Identifying the causes and cellular effects of Focal segmental glomerulosclerosis (FSGS) Dr Gavin WelshProf Moin Saleem Bristol Renal
Exploring the contribution of divergent neuroinflammation in Alzheimer’s disease Dr J JohnsonProf Patrick Kehoe Bristol CardioVascular
Assessing neuroinflammation and vascular dementia in association with atherosclerosis and aneurysm risk Dr J JohnsonProf Patrick Kehoe Bristol CardioVascular
Exploring the similarities between neointimal formation after vascular injury and tumour growth Dr Jason JohnsonProf Sarah George Bristol CardioVascular
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