The following list provides some potential research questions which could be asked using data from The Cleft Collective resource

Conception

1. What is the proportion of parents of a child with cleft who took class A drugs at the time of conception?
2. Is the proportion of parents who take/took class A drugs different in parents of a child with cleft to nationally reported data? 
3. Does intake of class A drugs differ between cleft type? (Numbers may be too small)
4. What is the proportion of parents of a child with cleft who took prescription drugs (breakdown into specific prescriptions) at the time of conception?
5. Is the proportion of parents who take/took prescription drugs (breakdown into specific prescriptions) different in parents of a child with cleft to nationally reported data? 
6. Does intake of prescription drugs (breakdown into specific prescriptions) differ between cleft type? (Numbers may be too small)
7. Does parental BMI at conception differ between cleft types?
8. Does parental BMI at conception differ to nationally reported data?
9. What proportion of parents with a child affected by cleft have received assisted conception?
10. Do proportions of assisted conceptions differ in the cleft population and nationally reported data?
11. Which supplements were taken by mums around the time their child was conceived and during the first three months of pregnancy?

 Wellbeing

1. Is self-reported child appearance associated with SDQ?
2. Is self-reported child appearance associated with parental wellbeing?
3. Is self-reported child appearance associated with teasing and bullying?
4. How does self-reported child appearance change over time?
5. How many families have hereditary cleft reported in family members?
6. Is cleft diagnosis timing associated with parental mental health?
7. Is cleft severity associated with parental mental health?
8. Comparison of maternal-paternal mental health in cleft
9. Is there an association between parental satisfaction with healthcare and parental wellbeing?

Child's growth

1. Does weight/height/BMI of the child differ by cleft type?
2. Does head circumference of the child differ by cleft type?

Co-morbidities

1. Profiling of parental co-morbidities

Feeding/Eating

1. What impact does a cleft have on feeding a child with different types of cleft?
2. Do eating behaviours differ between cleft types?

Speech & Language

1. How does number of child vocalisations at age 13 months vary by cleft type?
2. How does number of child vocalisations at age 13 months vary by Socio Economic Status?
3. How does number of adult words at age 13 months vary by cleft type?
4. How does number of adult words at age 13 months vary by Socio Economic Status?
5. How does number of conversational turns at age 13 months vary by cleft type?
6. How does number of conversational turns at age 13 months vary by Socio Economic Status?
7. How does ratio of canonical to non-canonical babbling at age 13 months vary by cleft type?
8. How does ratio of canonical to non-canonical babbling at age 13 months vary by Socio Economic Status?
9. Is there an association between quality of a child's audio environment and speech at age 13 months (as measured by consonant inventory, number of vocalisations, type of babble)?
10. Is there a relationship between number of vocalisations at age 13 months and consonant inventory at age 24 months (as measured by number of different consonants heard in SLT assessment)?
11. Is there a relationship between consonant inventory at age 13 months and consonant inventory at age 24 months (as measured by number of different consonants heard in SLT assessment)?
12. Is there a relationship between babble ratio at age 13 months and consonant inventory at age 24 months (as measured by number of different consonants heard in SLT assessment)?
13. Is there a relationship between number of vocalisations at age 13 months and cleft speech characteristics at age 24 months (as measured by number of different consonants heard in SLT assessment)?
14. Is there a relationship between consonant inventory at age 13 months and cleft speech characteristics at age 24 months (as measured by number of different consonants heard in SLT assessment)?
15. Is there a relationship between babble ratio at age 13 months and cleft speech characteristics at age 24 months (as measured by number of different consonants heard in SLT assessment)?
16. Is there a relationship between number of vocalisations at age 13 months and resonance at age 24 months (as measured by number of different consonants heard in SLT assessment)?
17. Is there a relationship between consonant inventory at age 13 months and resonance at age 24 months (as measured by number of different consonants heard in SLT assessment)?
18. Is there a relationship between babble ratio at age 13 months and resonance at age 24 months (as measured by number of different consonants heard in SLT assessment)?
19. Is there a relationship between number of vocalisations at age 13 months and consonant inventory at age 36 months (as measured by number of different consonants heard in SLT assessment)?
20. Is there a relationship between consonant inventory at age 13 months and consonant inventory at age 36 months (as measured by number of different consonants heard in SLT assessment)?
21. Is there a relationship between babble ratio at age 13 months and consonant inventory at age 36 months (as measured by number of different consonants heard in SLT assessment)?
22. Is there a relationship between number of vocalisations at age 13 months and cleft speech characteristics at age 36 months (as measured by number of different consonants heard in SLT assessment)?
23. Is there a relationship between consonant inventory at age 13 months and cleft speech characteristics at age 36 months (as measured by number of different consonants heard in SLT assessment)?
24. Is there a relationship between babble ratio at age 13 months and cleft speech characteristics at age 36 months (as measured by number of different consonants heard in SLT assessment)?
25. Is there a relationship between number of vocalisations at age 13 months and resonance at age 36 months (as measured by number of different consonants heard in SLT assessment)?
26. Is there a relationship between consonant inventory at age 13 months and resonance at age 36 months (as measured by number of different consonants heard in SLT assessment)?
27. Is there a relationship between babble ratio at age 13 months and resonance at age 36 months (as measured by number of different consonants heard in SLT assessment)?

Hearing questions

1. Is there a difference between cleft types (UCLP, BCLP, CPO-hard & soft, CPO-soft only) in hearing / middle ear related features at 18 months? D3-8 in 18 months Q
2. Is there an association between parent reported hearing / middle ear indicators at 18 months and parent reported hearing / middle ear factors at 3 years?

Communication questions

1. Does early use of gesture vary between cleft types?

Genetics

1. Using MR which nutritional factors could be a risk factor for cleft
2. Using MR BMI could be a risk factor for cleft