Clinical and Health Service Research

Contact details

Contact details for individual members of the clinical and health services research group can be found in the People Directory

This research is concerned with early diagnosis/screening and improving the management and outcome of cancer. There are international leading research groups in prostate cancer, brain tumours, surgical treatment and appearance/outcomes/MDT/quality of life research. Bristol also leads the cancer network within the National School for Primary Care Research.

The diagnosis and treatment of prostate cancer are being investigated in the ProtecT (Prostate testing for cancer and Treatment) study and associated ProMPT (Prostate Mechanisms of Progressing and Treatment) collaboration.  Issues involved in population screening for prostate cancer are also being addressed in the CRUK-funded CAP (screening Comparison Arm for ProtecT) study.  These linked studies (ProtecT and ProMPT are nested within the intervention arm of the CAP trial) are now the largest in the world, involving over 450,000 men.  Around 100,000 donated blood samples, 5,000 biopsy samples and 1,500 have undergone radical prostatectomy.  These linked studies are also providing a focus for biomarker discovery and evaluation.  

Research is also focused on the development and evaluation of cancer biomarkers (eg fascin, IGFBP-2), particularly in the areas of breast and prostate cancer. 

There are two fully registered UK CRC trial units in Bristol, the Bristol Randomised Trials Collaboration (BRTC) and the Clinical Trials Evaluation Unit (CTEU). Their aim is to provide leadership and support in the design, conduct and analysis of pragmatic randomised trials that address questions of importance to the NHS.

The NIHR-funded Head and Neck 5000 study will provide detailed information on the factors that influence cancer survival in the UK, and the psychological impact that living with head and neck cancer can have on people. 

Through the Biomedical Research Unit in Nutrition, Diet and Lifestyle we are translating our epidemiological findings into experimental interventions that investigate the effect of dietary and physical activity interventions on prostate cancer progression. 

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