Postgraduate publications

A selection of publications from our PhD students.

2012

Curnow, P., Senior, L., Knight, M.J, Thamatrakoln, K., Hildebrand, M. and Booth, P.J. 2012. Expression, purification, and reconstitution of a diatom silicon transporter. Biochemistry 51, 3776−3785.

Joyce, P.I., Satija, R., Chen, M and Kuwabara, P.E. 2012. The atypical calpains: Evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration. PLoS Genet. 3:e1002602

Rusling, D.A., Laurens, N., Pernstich, C., Wuite, G.J.L. & Halford, S.E. 2012. DNA looping by FokI: the impact of synapse geometry on loop topology at varied site orientations. Nucleic Acids Res., in press (doi:10.1093/nar/gks183).

Pernstich, C. & Halford, S.E. 2012. Illuminating the reaction pathway of the FokI restriction endonuclease by fluorescence resonance energy transfer. Nucleic Acids Res., 40, 1203-1213.

Hizlan, D., Robson, A., Whitehouse, S., Gold, V.A., Vonck, J., Mills, D.J., Kühlbrandt, W. & Collinson, I. (2012). Structure of the SecY complex unlocked by a pre-protein mimic. Cell Reports 1, 21-28.

Kelly, D., Dillingham., M, Hudson, A, and Wiesner, K. 2012. A New Method for Inferring Hidden Markov Models from Noisy Time Sequences. PLoS One, 7(1):e29703.

Saikrishnan, K., Yeeles, J.T., Gilhooly, N., Krajewski, W.W., Dillingham, M.S. and Wigley, D.B. 2012. Insights into Chi recognition from the structure of an AddAB-type helicase-nuclease complex  EMBO J., 31, 1568-78.

Agnew, C.R.J., Warrilow, A.G.S., Burton, N.M., Lamb, D.C., Kelly, S.L & Brady, R.L. 2012. An enlarged, adaptable active site in CYP164 family P450 enzymes, the sole P450 in Mycobacterium leprae. Antimicrob. Agents Chemother. 56(2), 391-402.

Betin, V.M.S., MacVicar, T.B.D., Parsons, S.F., Anstee, D.J, Lane, J.D. 2012. A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress. Autophagy in press.

Griffiths, R.E., Kupzig, S., Cogan, N., Mankelow, T.J., Betin, V.M.S., Trakarnsanga, K., Massey, E.J., Lane, J.D., Parsons, S.F., Anstee, D.J. 2012. Maturing reticulocytes internalise plasma membrane in Glycophorin A- containing vesicles which fuse with autophagosomes prior to exocytosis. Blood in press.

2011

Halford, S.E., Catto, L.E., Pernstich, C., Rusling, D.A. & Sanders, K.L. 2011. The reaction mechanism of FokI excludes the possibility of targeting zinc finger nucleases to unique DNA sites. Biochem. Soc. Trans., 39, 584–588.

Deville, K., Gold, V.A.M., Robson, A., Whitehouse, S., Sessions, R.B., Baldwin, S.A., Radford, S.E. & Collinson, I. 2011. Stoichiometry and structure of the active membrane-bound bacterial translocon. J. Biol. Chem. 286, 4659-69.

Kantamneni, S., Wilkinson, K.A., Jaafari, N., Ashikaga, E., Rocca, D., Rubin, P., Jacobs, S., Nishimune, A. and Henley, J.M. 2011. Activity dependent SUMOylation of the brain specific scaffolding protein GISP Biochem. Biophys. Res. Com. 409, 657-62.

McMillan, L., Brown, J.T., Dasso, M., Henley, J.M. and Cimarosti, H. 2011. Profiles of SUMO and Ubiquitin Conjugation in an Alzheimer’s Disease Model. Neurosci. Lett. 502, 201-8.

Cimarosti, H., Ashikaga, E., Jaafari, N., Dearden, L., Rubin, P., Wilkinson, K.A. and Henley, J.M. 2011. Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones J.Cereb.Blood Flow Metab. DOI jcbfm2011146 [pii]10.1038/jcbfm.2011.146

Singleton, B.K., Lau, W., Fairweather, V.S.S., Burton, N.M., Wilson, M.C., Parsons, S.F., Richardson B.M., Trakarnsanga, K., Brady, R.L., Anstee, D.J. and Frayne J. 2011. Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes. Blood 118: 3137-3145.

Yeeles, J.T.P., van Aelst, K, Dillingham, M.S. and Moreno-Herrero, F. 2011. Recombination hotspots and single-stranded DNA binding proteins couple DNA translocation to DNA unwinding by the AddAB helicase-nuclease.

Budnik, A., Heesom, K.J., and Stephens, D.J. 2011. Characterization of human Sec16B: indications of specialized, non-redundant functions. Scientific Reports 1, 77. DOI:10.1038/srep00077.

Hunt, S.D. and Stephens, D.J. 2011. The role of motor proteins in endosomal sorting. Biochemical Society Transactions. 39, 1179-1184. doi:10.1042/BST0391179

Simister, P.C., Burton, N.M., & Brady, R.L. 2011. Phosphotyrosine recognition by the Raf kinase inhibitor protein. Forum on Immunopathological Diseases & Therapeutics 2, 59-70.

Chaikuad, A., Shafqat N, A.l., Mokhtar, R., Cameron, A., Clarke, A.R., Brady, R.L., Oppermann, U., Frayne, J, & Yue, W.W. 2011. Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS. Biochem. J. 435, 401-409 doi:10.1042/BJ20101442

Brown, C., Campos-Leon, K., Strickland, M., Williams, C., Fairweather, V., Brady, R.L., Crump, M.P. & Gaston, K. 2011. Protein flexibility directs DNA recognition by the papillomavirus E2 proteins. Nucleic Acids Research 39(7), 2969-2980.

Singleton, B.K., Lau, W., Fairweather, V.S., Burton, N.M., Wilson, M.C., Parsons, S.F., Richardson, B.M., Trakarnsanga, K., Brady, R.L., Anstee, D.J & Frayne, J. 2011. Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes. Blood 118(11), 3137-45.

Agnew, C., Borodina, E., Zaccai, N.R., Conners, R., Burton, N.M., Vicary, J.A., Cole, D.K., Antognozzi, M., Virji, M., & Brady, R.L. 2011. Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding. PNAS (USA) 108(37), 15174-15178 doi:10.1073/pnas.1106341108.

Ambre, P.K., Pissurlenkar, R.R.S., Jagyasi, A.S., Fule, R.A., Khedkar, V., Barhate, C.R., Vivas, L., Tripathi, A.K.,Sullivan, D., Birkinshaw, R., Brady, R.L., Iyer, K and Coutinho, E.C. 2011. Molecular Modeling Studies, Synthesis and Biological Evaluation of Novel Plasmodium falciparum Lactate Dehydrogenase (pfLDH) Inhibitors. Anti-Infective Agents 10(1), 55-71.

Zaccai, N.R., Chi, B., Thomson, A.R., Boyle, A.L., Bartlett, G.J., Bruning, M., Linden, N., Sessions, R.B., Booth, P.J., Brady, R.L., Woolfson, D.N. 2011. Nat. Chem. Biol.7, 935-941.

Harris, N.J. & Booth, P.J. 2011. Folding and stability of membrane transport proteins in vitro. Biochim. Biophys. Acta 1818, 1055-66.

Humphrey, S., Clark L.F., Humphrey, T.J., Jepson, M.A. 2011. Enhanced recovery of Salmonella Typhimurium DT104 from exposure to stress at low temperature. Microbiology 157: 1103-1114.

Humphrey, S., MacVicar, T., Stevenson, A., Roberts, M., Humphrey, T.J. & Jepson, M.A. 2011. SulA-induced filamentation in Salmonella enterica serovar Typhimurium: Effects on SPI-1 expression and epithelial infection J. Appl. Microbiol. 111: 185-96.

Clark, L., Perrett, C.A., Malt, L., Harward, C., Humphrey, S., Jepson, C.A., Martinez-Argudo, I., Carney, L.J., La Ragione, R.M., Humphrey, T.J. & Jepson, M.A. 2011. Differences in Salmonella enterica serovar Typhimurium strain invasiveness are associated with heterogeneity in SPI-1 gene expression. Microbiology 157: 2072-83.

Purcell, O., di Bernardo, M., Grierson, C.S. and Savery, N.J. 2011. A multi-functional synthetic gene network: a frequency multiplier, oscillator and switch. PLoS One, 6, e16140.

2010

Hanley, L.J., and Henley, J.M. 2010. Differential roles of GRIP1a and GRIP1b in AMPA receptor trafficking. Neurosci. Lett. 485, 167-172.

Gold, V. A., Robson, A., Bao, H., Romantsov, T., Duong, F. & Collinson, I. 2010. The action of cardiolipin in bacterial protein translocation. Proc Natl Acad Sci U S A. 107, 10044-9.

Hughes, H. and Stephens, D.J. 2010. Sec16A defines the initiation site for vesicle budding from the endoplasmic reticulum on exit from mitosis. Journal of Cell Science 123, 4032-8. doi: 10.1242/jcs.076000.

Cheng, J.P.X., Betin, V.M.S., Weir, H., Shelmani, G.M.A., Moss, D.K & Lane, J.D. 2010. Caspase cleavage of the Golgi stacking factor GRASP65 is required for Fas/CD95-mediated apoptosis. Cell Death & Disease 1, e82; doi:10.1038/cddis.2010.59.

Cheng, J.P.X & Lane, J.D. 2010. Organelle dynamics and membrane trafficking in apoptosis and autophagy. Histology & Histopathology 25: 1457-1472.

Manelyte, L., Kim, Y.T., Smith, A.J., Smith, R.M., and Savery, N.J. 2010. Regulation and rate enhancement during Transcription-coupled repair. Molecular Cell. 40, 714-724.

Purcell, O., Savery, N.J., Grierson, C.S., and di Bernardo, M. 2010. A comparative analysis of synthetic genetic oscillators. Journal of The Royal Society Interface, 7, 1503-1524.

2009

Frayne, J., Taylor A., Cameron G. & Hadfield A.T. (2009) Structure of insoluble rat sperm glyceraldehydes-3-phospate dehydrogenase (GAPDH) via heterotetramer formation with Escherichia coli GAPDH reveals target for contraceptive design. J. Biol. Chem., 284, 22703-22712.

Richardson B.M., Heesom K.J., Parsons S.F., Anstee D.J. & Frayne J. (2009). Analysis of the differential proteome of human erythroblasts during in vitro erythropoiesis by 2-D DIGE. Proteomics Clin. Appl., 3, 1123-1134.

Yeeles, J.T., R. Cammack, and M.S. Dillingham. 2009. An iron-sulfur cluster is essential for the binding of broken DNA by AddAB-type helicase-nucleases. J Biol Chem. 284:7746-55.

Scott, A., and H. Mellor. 2009. VEGF receptor trafficking in angiogenesis. Biochem Soc Trans. 37:1184-8.

Satchwell, T.J., D.K. Shoemark, R.B. Sessions, and A.M. Toye. 2009. Protein 4.2: a complex linker. Blood Cells Mol Dis. 42:201-10.

Robson, A., Gold, V. A., Hodson, S., Clarke, A. R. & Collinson, I. 2009. Energy transduction in protein transport and the ATP hydrolytic cycle of SecA. Proc Natl Acad Sci U S A 106: 5111-6

Hunter, R.W., C. Mackintosh, and I. Hers. 2009. Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets. J Biol Chem. 284:12339-48.

Hunter, R.W., and I. Hers. 2009. Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function. J Thromb Haemost. 7:2123-30.

Hughes, H., A. Budnik, K. Schmidt, K.J. Palmer, J. Mantell, C. Noakes, A. Johnson, D.A. Carter, P. Verkade, P. Watson, and D.J. Stephens. 2009. Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER. J Cell Sci. 122:2924-34.

Hamid, N.A., C. Brown, and K. Gaston. 2009. The regulation of cell proliferation by the papillomavirus early proteins. Cell Mol Life Sci. 66:1700-17.

Clark, L., I. Martinez-Argudo, T.J. Humphrey, and M.A. Jepson. 2009. GFP plasmid-induced defects in Salmonella invasion depend on plasmid architecture, not protein expression. Microbiology. 155:461-7.

Budnik, A., and D.J. Stephens. 2009. ER exit sites--localization and control of COPII vesicle formation. FEBS Lett. 583:3796-803.

Brown, E., J. Mantell, D. Carter, G. Tilly, and P. Verkade. 2009. Studying intracellular transport using high-pressure freezing and Correlative Light Electron Microscopy. Semin Cell Dev Biol. 20:910-9.

Brown, A.C., D. Hallouane, W.J. Mawby, F.E. Karet, M.A. Saleem, A.J. Howie, and A.M. Toye. 2009. RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels. Am J Physiol Renal Physiol. 296:F1279-90.

Betin, V.M., and J.D. Lane. 2009. Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. J Cell Sci. 122:2554-66.

Betin, V.M., and J.D. Lane. 2009. Atg4D at the interface between autophagy and apoptosis. Autophagy. 5:1057-9.

2008

Williamson, R.C., A.C. Brown, W.J. Mawby, and A.M. Toye. 2008. Human kidney anion exchanger 1 localisation in MDCK cells is controlled by the phosphorylation status of two critical tyrosines. J Cell Sci. 121:3422-32.

Williams, H., P.S. Jayaraman, and K. Gaston. 2008. DNA wrapping and distortion by an oligomeric homeodomain protein. J Mol Biol. 383:10-23.

Scott, A.N., C. Hetheridge, A.R. Reynolds, V. Nayak, K. Hodivala-Dilke, and H. Mellor. 2008. Farnesyltransferase inhibitors target multiple endothelial cell functions in angiogenesis. Angiogenesis. 11:337-46.

Marsh, M., D.K. Shoemark, A. Jacob, C. Robinson, B. Cahill, N.Y. Zhou, P.A. Williams, and A.T. Hadfield. 2008. Structure of bacterial glutathione-S-transferase maleyl pyruvate isomerase and implications for mechanism of isomerisation. J Mol Biol. 384:165-77.

Hunter, R.W., M.T. Harper, and I. Hers. 2008. The PKB inhibitor Akti-1/2 potentiates PAR-1-mediated platelet function independently of its ability to block PKB. J Thromb Haemost. 6:1923-32.

Hughes, H., and D.J. Stephens. 2008. Assembly, organization, and function of the COPII coat. Histochem Cell Biol. 129:129-51.

Betin, V.M., and J.D. Lane. 2008. The cytoskeleton and the control of organelle dynamics in the apoptotic execution phase. SEB Exp Biol Ser. 59:267-89.

2007

Hughes H, Stephens DJ. (2007) Assembly, organization, and function of the COPII coat. Histochem Cell Biol. [Epub ahead of print]

McKibbin C, Farmer NA, Jeans C, Reeves PJ, Khorana HG, Wallace BA, Edwards PC, Villa C, Booth PJ. (2007) Opsin stability and folding: modulation by phospholipid bicelles. J Mol Biol 374, 1319-1332.

Crisp J, Conners R, Garrity JD, Carenbauer AL, Crowder MW, Spencer J. (2007) Structural basis for the role of Asp-120 in metallo-beta-lactamases. Biochemistry 18, 10664-10674.

Gold VA, Duong F, Collinson I. (2007) Structure and function of the bacterial Sec translocon. Mol Membr Biol. 24, 387-394.

Tyka MD, Sessions RB, Clarke AR. (2007) Absolute free-energy calculations of liquids using a harmonic reference state. J Phys Chem B. 111, 9571-9580.

Green KL, Brown C, Roeder GE, Southgate TD, Gaston K. (2007) A cancer cell-specific inducer of apoptosis. Hum Gene Ther. 18, 547-561.

Yeeles JT, Dillingham MS. (2007) A dual-nuclease mechanism for DNA break processing by AddAB-type helicase-nucleases. J Mol Biol. 371, 66-78.

Bujny MV, Popoff V, Johannes L, Cullen PJ. (2007) The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network. J Cell Sci. 120, 2010-2021.

Gold VA, Robson A, Clarke AR, Collinson I. (2007) Allosteric regulation of SecA: Magnesium-mediated control of conformation and activity. J Biol Chem. 282, 17424-17432 .

Marshall JJ, Gowers DM, Halford SE. (2007) Restriction endonucleases that bridge and excise two recognition sites from DNA. J Mol Biol. 367, 419-431.

Evans IR, Renne T, Gertler FB, Nobes CD (2007) Ena/VASP proteins mediate repulsion from ephrin ligands. J Cell Sci 120, 289-298.

Manoharan C, Wilson MC, Sessions RB, Halestrap AP. (2007) The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity. Mol Membr Biol 23, 486-498.

McGivan JD, Bungard CI. (2007) The transport of glutamine into mammalian cells. Front Biosci. 12, 874-882.

Mountjoy PD, Bailey SJ, Rutter GA. (2007) Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity. Diabetologia. 50, 168-177.

2006

Yarwood S, Bouyoucef-Cherchalli D, Cullen PJ, Kupzig S. (2006) The GAP1 family of GTPase-activating proteins: spatial and temporal regulators of small GTPase signalling. Biochem Soc Trans. 34, 846-850.

An R, da Silva Xavier G, Hao HX, Semplici F, Rutter J, Rutter GA. (2006) Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic beta-cells. Biochem Soc Trans. 34, 791-793.

Rutherford AC, Traer C, Wassmer T, Pattni K, Bujny MV, Carlton JG, Stenmark H, Cullen PJ. (2006) The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. J Cell Sci 119, 3944-3957.

Stanley LK, Szczelkun MD. (2006) Direct and random routing of a molecular motor protein at a DNA junction. Nucleic Acids Res 34, 4387-4394.

Tyka MD, Clarke AR, Sessions RB. (2006) An efficient, path-independent method for free-energy calculations. J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 110, 17212-17220.

Green KL, Gaston K. (2006) Development of a topical protein therapeutic for human papillomavirus and associated cancers. BioDrugs. 20, 209-218.

Parton LE, McMillen PJ, Shen Y, Docherty E, Sharpe E, Diraison F, Briscoe CP, Rutter GA. (2006) Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker Diabetic Fatty rat islets: a functional and gene profiling analysis. Am J Physiol Endocrinol Metab. 291, E982-994.

Booth MP, Conners R, Rumsby G, Brady RL. (2006) Structural Basis of Substrate Specificity in Human Glyoxylate Reductase/Hydroxypyruvate Reductase. J Mol Biol. 360, 178-189.

Stanley LK, Seidel R, van der Scheer C, Dekker NH, Szczelkun MD, Dekker C. (2006) When a helicase is not a helicase: dsDNA tracking by the motor protein EcoR124I. EMBO J. 25, 2230-2239.

Parish JL, Kowalczyk A, Chen HT, Roeder GE, Sessions R, Buckle M, Gaston K. (2006) E2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell death. J Virol. 80, 4580-4590.

Soufi A, Smith C, Clarke AR, Gaston K, Jayaraman PS. (2006) Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain. J Mol Biol. 358, 943-962.

Conners R, Hooley E, Clarke AR, Thomas S, Brady RL. (2006) Recognition of oxidatively modified bases within the biotin-binding site of avidin. J Mol Biol. 357, 263-274.

Soufi A, Gaston K, Jayaraman PS. (2006) Purification and characterisation of the PRH homeodomain. Int J Biol Macromol. [Epub ahead of print]

Ullah MS, Davies AJ, Halestrap AP. (2006) The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1alpha-dependent Mechanism. J Biol Chem. 281, 9030-9037.

Forster R, Weiss M, Zimmermann T, Reynaud EG, Verissimo F, Stephens DJ, Pepperkok R. (2006) Secretory cargo regulates the turnover of COPII subunits at single ER exit sites. Curr Biol. 16, 173-179.

Green KL, Southgate TD, Mulryan K, Fairbairn LJ, Stern PL, Gaston K. (2006) Diffusible VP22-E2 Protein Kills Bystander Cells and Offers a Route for Cervical Cancer Gene Therapy. Hum Gene Ther. 17, 147-157.

2005

Kowalczyk AM, Roeder GE, Green K, Stephens DJ, Gaston K (2005) Measuring the induction or inhibition of apoptosis by HPV proteins. Methods Mol Med. 119, 419-132.

Chaikuad A, Fairweather V, Conners R, Joseph-Horne T, Turgut-Balik D, Brady RL. (2005) Structure of Lactate Dehydrogenase from Plasmodium vivax: Complexes with NADH and APADH. Biochemistry44, 16221-16228.

Carlton JG, Cullen PJ. (2005) Sorting nexins. Curr Biol. 15, R819-820.

Bungard CI, McGivan JD. (2005) Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers. Arch Biochem Biophys. 443, 53-59.

Watson AJ, Fyfe PK, Frolov D, Wakeham MC, Nabedryk E, van Grondelle R, Breton J, Jones MR.(2005) Replacement or exclusion of the B-branch bacteriopheophytin in the purple bacterial reaction centre: the H(B) cofactor is not required for assembly or core function of the Rhodobacter sphaeroides complex. Biochim Biophys Acta 1710, 34-46.

Carlton JG, Bujny MV, Peter BJ, Oorschot VM, Rutherford A, Arkell RS, Klumperman J, McMahon HT, Cullen PJ. (2005) Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. J Cell Sci. 118, 4527-4539.

Watson AJ, Hughes AV, Fyfe PK, Wakeham MC, Holden-Dye K, Heathcote P, Jones MR. (2005) On the Role of Basic Residues in Adapting the Reaction Centre-LH1 Complex for Growth at Elevated Temperatures in Purple Bacteria. Photosynth Res. 86, 81-100.

Carlton JG, Cullen PJ. (2005) Coincidence detection in phosphoinositide signaling. Trends Cell Biol. 15, 540-547.

Sears A, Szczelkun MD. (2005) Subunit assembly modulates the activities of the Type III restriction-modification enzyme PstII in vitro. Nucleic Acids Res. 33, 4788-4796.

Palmer KJ, Konkel JE, Stephens DJ. (2005) PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport. J. Cell Sci. 118, 3839-3847.

Sears A, Peakman LJ, Wilson GG, Szczelkun MD. (2005) Characterization of the Type III restriction endonuclease PstII from Providencia stuartii. Nucleic Acids Res. 33, 4775-4487.

Dempsey CE, Piggot TJ, Mason PE (2005) Dissecting contributions to the denaturant sensitivities of proteins. Biochemistry 44, 775-781.

Hildyard JC, Ammala C, Dukes ID, Thomson SA, Halestrap AP (2005) Identification and characterisation of a new class of highly specific and potent inhibitors of the mitochondrial pyruvate carrier. Biochim Biophys Acta. 1707, 221-30.

Smith AJ, Savery NJ. (2005) RNA polymerase mutants defective in the initiation of transcription-coupled DNA repair. Nucleic Acids Res. 33, 7557-64.

Carlton J, Bujny M, Rutherford A, Cullen P. (2005) Sorting nexins - unifying trends and new perspectives. Traffic 6, 75-82.

2004

Berwick DC, Dell GC, Welsh GI, Heesom KJ, Hers I, Fletcher LM, Cooke FT, Tavare JM. (2004) Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles. J Cell Sci. 11, 5985-5993.

Mankelow TJ, Hu XW, Adams K, Henderson LM. (2004) Investigation of the contribution of histidine 119 to the conduction of protons through human Nox2. Eur J Biochem. 271, 4026-4033.

Carlton J, Bujny M, Peter BJ, Oorschot VM, Rutherford A, Mellor H, Klumperman J, McMahon HT, Cullen PJ. (2004) Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. Curr Biol. 14, 1791-1800.

Curnow P, Lorch M, Charalambous K, Booth PJ. (2004) The reconstitution and activity of the small multidrug transporter EmrE is modulated by non-bilayer lipid composition. J Mol Biol. 343, 213-222.

Allen SJ, Curran AR, Templer RH, Meijberg W, Booth PJ. (2004) Controlling the folding efficiency of an integral membrane protein.
J Mol Biol. 342, 1293-1304.

Allen SJ, Curran AR, Templer RH, Meijberg W, Booth PJ. (2004) Folding kinetics of an alpha helical membrane protein in phospholipid bilayer vesicles.
J Mol Biol. 342, 1279-1291.

Hearn AR, De Haan L, Pemberton AJ, Hirst TR, Rivett AJ (2004) Trafficking of exogenous peptides into the proteasome-and TAP-dependent MHC class I pathway following enterotoxin B subunit-mediated delivery. J. Biol. Chem. 279, 51315-51322.

Wherlock M, Gampel A, Futter C, Mellor H (2004) Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase. J. Cell Sci. 117, 3221-3231.

Swingler TE, Bess KL, Yao J, Stifani S, Jayaraman PS (2004) The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells. J. Biol. Chem. 279, 34938-34947.

Rivett AJ, Hearn AR (2004) Proteasome function in antigen presentation: immunoproteasome complexes, Peptide production, and interactions with viral proteins. Curr. Protein Pept. 5, 153-161.

Bungard CI, McGivan JD (2004) Glutamine availability up-regulates expression of the amino acid transporter protein ASCT2 in HepG2 cells and stimulates the ASCT2 promoter. Biochem. J. 382, 27-32.

Poso D, Clarke AR, Burston SG (2004) Identification of a Major Inter-ring Coupling Step in the GroEL Reaction Cycle. J. Biol. Chem. 279, 38111-38117.

Astin J, Merry A, Rajan J, Kuwabara PE (2004) Caenorhabditis elegans functional genomics: omic resonance. Brief Funct. Genomic Proteomic. 3, 26-34.

Parton LE, Diraison F, Neill SE, Ghosh SK, Rubino MA, Bisi JE, Briscoe CP, Rutter GA (2004) Impact of PPARgamma overexpression and activation on pancreatic islet gene expression profile analyzed with oligonucleotide microarrays. Am. J. Physiol. Endocrinol. Metab.287, E390-404.

Poso D, Clarke AR, Burston SG (2004) A kinetic analysis of the nucleotide-induced allosteric transitions in a single-ring mutant of GroEL. J. Mol. Biol. 338, 969-977.

Palmer KJ, Stephens DJ (2004) Biogenesis of ER-to-Golgi transport carriers: complex roles of COPII in ER export. Trends Cell Biol. 14, 57-61.

Wakeham MC, Breton J, Nabedryk E, Jones MR (2004) Formation of a semiquinone at the QB site by A- or B-branch electron transfer in the reaction center from Rhodobacter sphaeroides. Biochemistry 43, 4755-4763.

Pattni K, Banting G (2004) Ins(1,4,5)P3 metabolism and the family of IP3-3Kinases. Cell Signal. 16, 643-654.

Mitchell KJ, Tsuboi T, Rutter GA (2004) Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing. Diabetes 53, 393-400.