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Unravelling the biology of parkinsonism 22 August 2016 Scientists have taken another step towards understanding the causes of parkinsonism by identifying what's happening at a cellular level to potentially help develop future treatments.
  • Unravelling the biology of parkinsonism 22 August 2016 Scientists have taken another step towards understanding the causes of parkinsonism by identifying what's happening at a cellular level to potentially help develop future treatments.
  • Soapbox Science in Bristol 18 August 2016 Soapbox Science is a public outreach initiative aimed at promoting female scientists and the varied and fascinating research they do. Events take place in cities across the country, and this year the Bristol event covered everything from ‘Is stress killing your brain cells?’ to ‘The Magic of Mushrooms: could mushrooms be the solution to antibiotic resistance?’ to ‘Designing vaccine delivery systems using synthetic biology.’
  • Biochemistry undergraduate contributes to a paper on mitochondrial genetics 22 July 2016 The Szczelkun and Savery labs have published a new paper, 'Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity', in the journal Nucleic Acids Research.
  • Anthony Russell Clarke, 1959-2016 20 July 2016
  • Outreach Day at Fynamore School, Calne, Wiltshire 24 June 2016
  • Bristol and Leeds collaboration reveals a new mechanism for protein secretion 14 June 2016 In collaboration with the University of Leeds, the Collinson lab has discovered that a cell's protective layer acts like a turnstile, allowing proteins to be exported while preventing them from moving back in.
  • Bring out your Dead: How Cell Corpses Help Train the Immune System 27 May 2016 Engulfing the corpses of dead cells is an important “rite of passage” for macrophages, a type of white blood cell that forms part of the innate immune system. The biochemical changes that occur inside macrophages after consuming apoptotic cells primes them for tackling challenges like cuts and bacterial infection. This research, published recently in the journal Cell, was led by Dr Helen Weavers from the University of Bristol’s Faculty of Biomedical Sciences.
  • New insight into the mechanisms of collagen secretion 13 May 2016
  • An enzyme enigma discovered in the abyss 12 May 2016 Scientists at the Universities of Bristol and Newcastle have uncovered the secret of the ‘Mona Lisa of chemical reactions’ – in a bacterium that lives at the bottom of the Pacific Ocean. It is hoped the discovery could lead to the development of new antibiotics and other medical treatments.
  • A CRISPR view of MultiBac 4 May 2016 Multigene delivery and subsequent cellular expression is a key technology for a wide range of applications in biology including structural research, cellular reprogramming and functional pharmaceutical screening. The construction of multigene circuits in mammalian cells is a core concept in synthetic biology and requires efficient delivery of complex heterologous DNA. For certain cell types including widely used HEK293 and HeLa cells, this can be achieved by plasmid-based transfection. However, a large number of cell lines and particularly primary cells are recalcitrant to plasmid transfection, thus requiring a different approach. Primary cells are a central focus of current biological research efforts and multigene delivery in primary cells is highly desirable, but suitable tools were markedly lacking to date.
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