Bring out your Dead: How Cell Corpses Help Train the Immune System27 May 2016Engulfing the corpses of dead cells is an important “rite of passage” for macrophages, a type of white blood cell that forms part of the innate immune system. The biochemical changes that occur inside macrophages after consuming apoptotic cells primes them for tackling challenges like cuts and bacterial infection.
This research, published recently in the journal Cell, was led by Dr Helen Weavers from the University of Bristol’s Faculty of Biomedical Sciences.
An enzyme enigma discovered in the abyss12 May 2016Scientists at the Universities of Bristol and Newcastle have uncovered the secret of the ‘Mona Lisa of chemical reactions’ – in a bacterium that lives at the bottom of the Pacific Ocean. It is hoped the discovery could lead to the development of new antibiotics and other medical treatments.
A CRISPR view of MultiBac4 May 2016Multigene delivery and subsequent cellular expression is a key technology for a wide range of applications in biology including structural research, cellular reprogramming and functional pharmaceutical screening. The construction of multigene circuits in mammalian cells is a core concept in synthetic biology and requires efficient delivery of complex heterologous DNA. For certain cell types including widely used HEK293 and HeLa cells, this can be achieved by plasmid-based transfection. However, a large number of cell lines and particularly primary cells are recalcitrant to plasmid transfection, thus requiring a different approach. Primary cells are a central focus of current biological research efforts and multigene delivery in primary cells is highly desirable, but suitable tools were markedly lacking to date.
Pint of Science returns to Bristol27 April 2016Pint of Science returns for another year bringing cutting edge research to pubs all over Bristol. Bristol Biochemistry has contributed speakers and organisers over the years and Bristol Biochemistry postgrad Adam Jellett is one of this years' organisers.