Research areas

Our research interests relate to several key diseases and the pathogens that cause them. Many of these organisms colonise the upper respiratory tract of children and young adults.

They cause a wide range of diseases including acute otitis, meningitis, septicaemia and pneumonia.

The relationship between asymptomatic carriage and the development of invasive disease is not understood.

By studying the interaction of bacteria and the immune system in the carrier state, we hope to be able to design more effective vaccines for children.

Meningitis (Neisseria meningitidis, a.k.a. 'meningococcus')

The meningococcus is a bug that commonly lives at the back of the throat without causing any symptoms in people “carrying” it.

Meningitis and blood poisoning are very serious diseases, which can be caused by meningococcus (and some other bugs).

Although only very few people get these diseases, teenagers and young children are at increased risk.

We are interested in studying how many teenagers carry meningococci in their throat, whether they are carrying large numbers of bugs or just a few, and how this changes over time.

Other diseases

  • Pneumonia (Streptococcus pneumoniae, a.k.a. 'pneumococcus')
  • 'Flu' (influenza virus)
  • Diarrhoea and vomiting (rotavirus & norovirus)

NanoString Sprint machine

Following our successful bid, we are pleased to announce that our brand-new NanoString Sprint machine is in place and ready to be used in the C floor labs in the School of Cellular and Molecular Medicine, Biomedical Sciences Building.

 You can read about what this machine is used for here:

http://www.nanostring.com/products/nCounterSPRINT

In a nutshell, this is a means of accurately quantifying mRNA copies/transcripts of targeted genes in almost any biological sample.

It is also the only platform capable of simultaneous DNA RNA and proteomic readout on the same sample.

If you would like to use the machine and have a grant in place, a kit and samples to run, we can arrange a date for you to use the machine and undergo a training session.

If you would like to book a training session, please contact - Helen.Thompson@bristol.ac.uk - 0117 342 0172. It is a requirement that users undergo a training session before using the Nanostring machine.

NanoString costs:

  • £25 per sample for machine upkeep and stock reagents
  • Approximately £2800 for 50 target genes for 50 samples
  • £100 per person for training to use machine – once you have your samples and probe set.

Once trained, users are expected to run their own samples.

Users are asked to order their own consumables from NanoString which can be done via the NanoString website - https://www.nanostring.com/products/consumables

We look forward to hearing from you!

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