News

Popular drug combination for treatment resistant depression is not more effective than a single antidepressant in primary care

Psychiatrists and GPs increasingly combine mirtazapine with an SSRI (selective serotonin reuptake inhibitor) or SNRI (serotonin-noradenaline reuptake inhibitor) antidepressant for patients whose depression does not respond to a single antidepressant. A large clinical trial led by researchers at the Universities of Bristol, Exeter, Keele, Manchester and Hull York Medical School, and published in the British Medical Journal today, looked at the effectiveness of adding mirtazapine to an SSRI or SNRI in patients who remain depressed after at least six weeks of conventional (SSRI or SNRI) antidepressant treatment. They found that this combination was no more effective in improving depression than placebo and call on doctors to rethink its use.

Evidence for trauma-informed organisational change programmes

Trauma-informed organisational change programmes may improve conditions for staff and patients in primary care and community mental healthcare, according to University of Bristol-led research published in Health & Social Care in the Community. Evidence was very limited and conflicting, but researchers found potential improvements to: staff readiness and sense of community, patient readiness for disease management and their access to services, staff and patient safety and some patient health outcomes.

Experts call for health system change to tackle the challenge of multimorbidity in the NHS

The number of people with multiple long-term conditions, known as multimorbidity, is rising internationally, putting increased pressure on health care systems, including the NHS. Researchers from the 3D Study – the largest ever trial of a person-centred approach to caring for patients with multimorbidity in primary care - at the Universities of Bristol, Dundee, Manchester and Glasgow, are hosting a conference today [Thursday 25 October] with the Royal College of General Practitioners to discuss the challenges facing general practice and how the health care system needs to respond.

Is remote consulting compatible with personalised care or does something have to give?

Personalised care, which aims to give people more say in their healthcare, and Digital First Primary Care, a move towards remote consulting, are both important NHS England policies, but they can be in tension. A new report aims to explore this tension and understand how remote consulting could be best set up to support personalised care. The report was commissioned by the NHS Personalised Care Institute and was conducted by researchers from the National Institute for Health Research Applied Research Collaboration West (NIHR ARC West) and the Centre for Academic Primary Care (CAPC) at the University of Bristol.