Dr Raquel Granell
B.Sc.(Valencia), M.Sc.(Bristol), PhD (Bristol), M.Sc.
Expertise
I am a research statistician interested in understanding the environmental and genetic causes of allergic diseases such as asthma, eczema and food allergies.
Current positions
Research Fellow in Primary Care
Bristol Medical School (PHS)
Contact
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Biography
Her research has focused on the aetiology of asthma, lung function trajectories and multimorbidity. She has identified longitudinal patterns of asthma and eczema throughout childhood using latent class analysis and characterised these with environmental and genetic risk factors with the aim to improve understanding of allergic diseases and inform therapeutic development.
She recently took a new role and joined the CAESAR group directed by Prof. Matthew Ridd, and she continues to do research on eczema and food allergies.
Research interests
Following an undergraduate degree in Math and Statistics in Spain, Raquel completed her PhD in Medical Statistics in Bristol in 2007 on Structural Equations Modelling. Her first post-doctoral research focused on modelling longitudinal patterns of childhood wheeze in the Avon Longitudinal Study of Parents and Children (ALSPAC); This work culminated with the identification of six wheezing phenotypes from birth to 7 years published in Thorax in 2008, a paper that has been cited over 300 times. In 2010 Raquel was awarded a 4-year MRC population Health Scientist Fellowship to continue her research on phenotypes of asthma. In 2011, she published a follow up paper on the replication/validation of the wheezing phenotypes in an independent cohort (JACI 2011) and more recently the extended wheezing phenotypes from birth till adolescence (JACI 2016). Raquel has also been involved in a number of genetic association studies for asthma, allergic sensitization, asthma and hay fever, allergic rhinitis and lung function. In 2016 Raquel completed a master’s degree in Genetic Epidemiology and Bioinformatics by Cardiff University. She is currently working with STELAR UK cohorts (ALSPAC, MAAS, IoW, Ashford and SEATON) to identify more stable and consistent wheezing phenotypes and to investigate how these phenotypes differ genetically.
Projects and supervisions
Research projects
UNICORN (Unified Cohorts Research Network) - Disaggregating asthma
Principal Investigator
Managing organisational unit
Bristol Medical School (PHS)Dates
01/03/2020 to 29/02/2024
Thesis supervisions
Publications
Recent publications
12/08/2024Exploring the genetics of airflow limitation in lung function across the lifespan – a polygenic risk score study
EClinicalMedicine
Genome-wide association study of preserved ratio impaired spirometry (PRISm)
European Respiratory Journal
A history of asthma may be associated with grandparents' exposures to stress and cigarette smoking.
Frontiers in Toxicology
A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing
eLife
Lung function and cognitive ability in children: a UK birth cohort study
BMJ Open Respiratory Research