Dr Monica Gamez
I am interested in the role of heparan sulphate in the vasculature. More specifically, I am interested in its contribution to the maintenance of vascular permeability and how it can be therapeutically targeted in disease.
Research AssociateBristol Medical School (THS)
Upon moving to Bristol in 2013, she worked as a technican with Dr. Becky Foster in the Bristol Renal group where she became interested in the glycocalyx, a carbohydrate rich layer found on our blood vessels that is essential for vascular health. A few years later she undertook a PhD at University of Bristol Medical School in Translational Health Sciences under Dr. Becky Foster, where her project focused on the roel of heparan sulphate in the glycocalyx. She graduated with a PhD in 2020 and I is now a post doctoral researcher in the Bristol Renal group.
The SARS-CoV-2 Spike protein alters human cardiac pericyte function and interaction with endothelial cells through a non-infective mechanism involving activation of CD147 receptor signalling.
- Conference abstract
The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling
Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease
- E-pub ahead of print
VEGFC reduces glomerular albumin permeability and protects against alterations in VEGF receptor expression in diabetic nephropathy
Therapeutically Targeting Heparan Sulphate To Restore The Endothelial Glycocalyx In Diabetic Microvascular Disease