Dr Monica Gamez
I am interested in the role of heparan sulphate in the vasculature. More specifically, I am interested in its contribution to the maintenance of vascular permeability and how it can be therapeutically targeted in disease.
Research AssociateBristol Medical School (THS)
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In 2017 Monica began her PhD studies at the University of Bristol in the Bristol Renal group working under the supervision of Dr. Rebecca Foster, where her project focused on the role of heparan sulphate in the glycocalyx. She graduated with a PhD in 2020 and is now a post-doctoral researcher in the Bristol Renal group working with Dr. Rebecca Foster.
Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx
The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling
The SARS-CoV-2 Spike protein alters human cardiac pericyte function and interaction with endothelial cells through a non-infective mechanism involving activation of CD147 receptor signalling.
European Heart Journal
- Special issue
Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease
- E-pub ahead of print
Therapeutically Targeting Heparan Sulphate To Restore The Endothelial Glycocalyx In Diabetic Microvascular Disease