
Dr Becky Foster
B.Sc.(Wales), Ph.D.(Bristol)
Current positions
Associate Professor of Microvascular Medicine
Bristol Medical School (THS)
Contact
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Research interests
Becky Foster completed her BSc in Zoology at the University of Wales, Swansea in 1999. In 2001, she undertook a PhD in the Microvascular Research Laboratories, Department of Physiology, University of Bristol with Prof. Dave Bates and Dr Steve Harper, studying the role of vascular endothelial growth factor (VEGF)-A in podocyte biology, which she completed in 2004. Becky extended her interest in renal physiology as an MRC funded Post-doctoral research scientist in the Academic Renal Unit, School of Clinical Science @ North Bristol, University of Bristol with Prof Peter Mathieson and Prof Moin Saleem and later with Dr Simon Satchell. In 2010, she was awarded a BHF Intermediate Basic Science Research Fellowship to address the question "Can VEGF-C regulate VEGF-A induced changes in glomerular endothelial cell barrier properties in health and disease?" Since then she has been funded by the British Heart Foundation, Kidney Research UK, Diabetes Research and Wellness Foundation and European Foundation for the study of Diabetes. In 2015, she secured a lectureship at the University of Bristol and now splits her time between research and teaching. She is particularly interested in the contribution of the endothelial cell glycocalyx (the protective layer that lines all blood vessels) to vessel barrier function within the kidney and beyond. She aims to identify therapeutic approaches that can restore the endothelial glycocalyx which will be common across vessel beds and vascular diseases.
Projects and supervisions
Research projects
Determining The Therapeutic Potential Of Gene Therapy For Translation Of Glycocalyx Protection Strategies In Chronic Kidney Disease
Principal Investigator
Role
Co-Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
13/02/2024 to 12/02/2025
8067 GW4 INSPIRE Round 6
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
13/02/2023 to 13/02/2025
1479256
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
24/03/2022 to 23/03/2023
Endothelial glycocalyx restoration to prevent proteinuria-associated vascular damage
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
24/05/2021 to 15/07/2024
E544 Glycocalyx as a Marker of Adverse Pregnancy Outcome in Women with Pre-existing Diabetes Mellitus
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
31/10/2020 to 31/08/2022
Publications
Recent publications
01/06/2024Adiponectin Reduces Glomerular Endothelial Glycocalyx Disruption and Restores Glomerular Barrier Function in a Mouse Model of Type 2 Diabetes
Diabetes
Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes
Cardiovascular Diabetology
A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome
Kidney International
Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx
JCI Insight
Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events
Kidney International
Thesis
The effects of vascular endothelial growth factor on podocyte biology
Supervisors
Award date
01/01/2004