Dr Hannah Gill
Bsc (Hons), MB ChB, FRCA, PhD
Current positions
Honorary Senior Lecturer
School of Physiology, Pharmacology & Neuroscience
Contact
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Research interests
I am interested in the effects of anaesthetic drugs, particularly inhalational anaesthetics, on developing brain. Millions of fetuses, neonates and young children are exposed to anaesthetic drugs for surgery every year and clinical evidence suggests there is a small risk of detriment to long-term neurodevelopment, increased with longer cumulative exposure and earlier exposure.
Laboratory studies in immature rodents, pigs and non-human primates have shown an association between exposure to commonly used anaesthetic drugs and widespread increased apoptosis in the brain: this has also been associated with detrimental effects on neuro-behaviourial outcomes in rodents. Xenon, a noble gas, with anaesthetic properties has been shown to prevent apoptosis induced by isoflurane, a commonly used inhalational anaesthetic in immature rodent brain.
I am interested in studying the effects of mixtures of xenon and common inhalational anaesthetic in immature rodent models of anaesthesia and in human infants undergoing surgery, in particular, to establish methods to optimise translation between the two settings.
Publications
Recent publications
09/12/2022Surgical-PEARL protocol
BMJ Open
Airway management for dental clearance in a preschool child
Paediatric Anaesthesia
Early childhood general anesthesia and neurodevelopmental outcomes in the ALSPAC birth cohort
Anesthesiology
Perioperative management of oral cleft repair
Pediatric Anesthesia
The effects of xenon on sevoflurane anesthesia-induced acidosis and brain cell apoptosis in immature rats
Pediatric Anesthesia