Martin Group: inflammation in tissue repair and cancer
We model wound healing in several genetically tractable model organism from the fruit fly, Drosophila, through to zebrafish and mice, with the goal of uncovering fundamental mechanisms that will enable development of wound healing therapeutics for human patients. We know that inflammation causes fibrosis and is aberrant in chronic wounds and so we use Drosophila and the translucent zebrafish also to to make movies of leukocyte migration into the wound and to dissect the genetics of inflammatory cell recruitment towards tissue damage and its consequences. In Drosophila and mice we have used array approaches to identify re-epithelialisation genes and those associated with wound inflammation, in the hope that these might lead us towards therapeutic targets for kick-starting chronic wounds, and blocking inflammation-driven fibrosis, respectively.
Most recently we have become interested in exploring the parallels between wound healing and cancer, in particular investigating how the wound inflammatory response impacts on immune cell recruitment to nearby transformed cells and what might be the downstream consequences of this.
If you want to know more after scanning our website or maybe want to join us as a PhD student or post-doc then please get in touch and/or come visit us in Bristol (also home of Aardman Animations, Banksy and many other cool folk).