Pleural infection

Studies & trials

ACTion*
A local randomised feasibility trial comparing chest tube drainage to therapeutic aspiration in infected pleural effusions. This study is not yet published.
AUDIO
A national randomised feasibility trial exploring the role of pleural biopsies in the diagnosis of pleural infection. This study was published in 2018.
MIST2
A national randomised controlled trial exploring the benefit of intrapleural fibrinolytic and DNase in the management of pleural infection. This study was published in 2011.
MIST 3
A national randomised controlled trial exploring the feasibility of running a trial comparing surgery to intrapleural fibrinolytics in pleural infection. This study is currently recruiting.
PACT*
A local observational study examining the concentration of antibiotics within infected pleural effusions.
PILOT
An international observational cohort study exploring risk factors and outcomes in patients with pleural infection. This study is not yet published.
SPIRIT*
A national randomised feasibility trial exploring the role of medical thoracoscopy in the early management of pleural infection. This study is not yet published.