Malignant pleural effusions
Studies & trials
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IPC-Plus*
A national randomised controlled trial comparing the effects of delivering talc slurry through an indwelling pleural catheter (IPC) with using an IPC alone. This study was published in 2018.
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OPTIMUM
A national randomised controlled trial exploring the combination of talc slurry and pleural manometry with indwelling pleural catheters. This study is not yet published.
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SEAL-MPE*
A first-in-human safety trial of a drug-eluting indwelling pleural catheter. This study was published in 2018.
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SIMPLE
A biobank and national randomised controlled trial examining if thoracic ultrasound can improve the success of talc pleurodesis. This study is not yet published.
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TAPPS*
A national randomised controlled trial comparing the effectiveness of chest drain and talc slurry with medical thoracoscopy and talc poudrage. This study was published in 2019.
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TIME2
A national randomised controlled trial comparing indwelling pleural catheters with chest drain and talc pleurodesis for managing breathlessness. This study was published in 2012.
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TIME3
A national randomised controlled trial exploring if intrapleural fibrinolytic is able to improve pleurodesis in patients with complicated malignant pleural effusion. This study was published in 2018.
Almost any cancer can spread from elsewhere in the body to affect the pleura, although this occurs most commonly with lung and breast cancers. This usually results in an effusion and associated breathlessness.
Malignant pleural effusions
are thought to affect over 50,000 people each year in the UK and many more worldwide.
For more information on our current and past malignant pleural effusion study involvement, follow the links to left (* indicates Bristol led)
