Inflammatory eye disease

Active research interests and expertise of the group are focussed on interrogating the mechanisms of immune-mediated inflammation and tissue damage which characterize inflammatory, neovascular and degenerative diseases of the eye.

Using animal models of ocular disease facilitates detailed understanding of the immune responses and dysregulated tissue responses which cause tissue damage, and this enhances understanding of analogous changes seen in the human eye.

The information from these studies informs the development of new treatments and the translation of therapeutic approaches designed to suppress dangerous immune responses and promote normal tissue homeostasis in the eye.


There are 8 main projects currently.


ORBIT consortium (Universities of Oxford, Bristol, Birmingham, Liverpool)
Dr Ying Kai-Chan, Harvard Business School, Boston, MA, USA
Professor Russ van Gelder & Dr Kathryn Pepple, University of Washington, Seattle, USA
Professor Alastair Denniston & Dr Lisa Hill, University of Birmingham, UK
Dr Gareth Jones, Cellular & Molecular Medicine, University of Bristol
Professor Alin Achim, Computational Imaging, University of Bristol
Dr Ali Bienemann & Dr Will Singleton, THS, University of Bristol
Dr Jesse Schallek, Flaum Eye Institute, University of Rochester

Current Funding

NIHR Biomedical Research Centre, Ophthalmology (Moorfields & UCL)

Sight Research UK (SRUK)

Fight for Sight

Above & Beyond

The Underwood Trust

The Macular Society

Wellcome Trust

Moorfields Eye Charity

University of Seattle

Janssen Pharmaceutica

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