Dr Jian Liu
BSc(Wuhan), MSc(Wuhan), PhD(Rostock)
Current positions
Senior Research Associate
Bristol Medical School (THS)
Contact
Press and media
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Research interests
Cellular and molecular mechanisms of immune dysregulation in ocular degenerative diseases.
Manipulation of immune and metabolic processes to rebuild tissue homeostasis and function in the eye.
Development of viral or non-viral therapeutic approaches using a combination of in vitro and in vivo models.
Projects and supervisions
Research projects
Large animal safety testing of a novel gene therapy for age-related macular degeneration (AMD), MRC IAA Funding
Role
Co-Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/07/2023 to 29/02/2024
Manipulating immune regulators that maintain retinal pigment epithelial health and metabolism as a therapeutic strategy for AMD (Macular Society)
Role
Co-Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
25/04/2022 to 24/05/2025
283069: Targeting autophagy to treat Age-related Macular Degeneration (NERC)
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/04/2021 to 31/03/2024
The role of negative immune regulators in oxidative stress-induced retinal degeneration (Rosetrees Trust)
Role
Co-Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/05/2018 to 31/12/2020
RPE degeneration and inflammasome activation in the progression of AMD (Rosetrees Trust)
Role
Co-Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/07/2014 to 31/12/2016
Publications
Recent publications
05/06/2024Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration
Science Translational Medicine
Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration
bioRxiv
The first dinosaurs in China
Gondwana Research
Recent developments of neuroprotective agents for degenerative retinal disorders
Neural Regeneration Research
Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration
Journal of Neuroinflammation