Professor Andrew Dick
B.Sc., M.B.B.S.(Lond.), M.D.(Aberd.), M.R.C.P.(UK), F.R.C.S.(Lond.), F.R.C.S.(Edin.), F.R.C.P.(Edin.), F.R.C.Ophth, FMedSci
Current positions
Professor of Ophthalmology
Bristol Medical School (THS)Professor of Ophthalmology
School of Cellular and Molecular Medicine
Contact
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Research interests
Group: Inflammatory Eye Disease Group
My group's work and that of others in ophthalmology focuses on how the retina responds to injury, inflammation and degeneration. This covers areas which include:
- The control of immune responses in the retina which includes for example the interaction with microglia and inhibitory signals mediated by neuronal CD200 expression
- Autoimmune responses within the eye and brain, by studying both T cell and macrophage responses within the tissue during experimental retinal and CNS autoimmunity
- Microglial and macrophage behaviour during retinal degeneration by studying experimental models of photoreceptor degeneration
- Retinal remodelling by studying the interaction of microglia, Muller cells and retinal progenitor cells
- Role of macrophages in retinal and choroidal angiogenesis
- Development of immunomodulatory agents for the treatment of uveitis, investigated in the experimental model of uveitis
Clinically we are undertaking significant advances in human ocular immunology through both our lead of Inflammation and immunotherapeutics of Biomedical Research Centre at Moorfields Eye Hospital and UCL-Institute of Ophthalmology. This includes:
(i) proof of concept early phase trials of immunotherapeutics.
(ii) Understanding of immune responses via live in vivo imaging of leukocytes through the retinal and choroidal vasculature in man.
(iii) progressing with development of gene therapy for treatment of uveitis
Present collaborators
- Dr Lindsay Nicholson, Schoool of Cellular and Molecular Medicine
- Dr Richard Lee, School of Clinical Sciences
- Dr Denize Atan, School of Clinical Sciences
- Dr Bob Nussenblatt, National Eye Institute, USA
- Professor R Ali, Institute of Ophthalmology and Institute of Child Health, UCL
- Professor John Forrester, University of Aberdeen
- Professor Jim Bainbridge, Institute of Ophthalmology, UCL
- Professor Mike Boulton, Indiana University School of Medicine
Projects and supervisions
Publications
Recent publications
01/01/2024Establishing the Normative Data Set Necessary for Imaging-Based Childhood Uveitis Surveillance
Investigative Ophthalmology and Visual Science
Filgotinib in Active Noninfectious Uveitis
JAMA Ophthalmology
Imaging-based detection of anterior chamber inflammation
American Journal of Ophthalmology
Integration of genetic and clinical risk factors improves the risk classification of uveitis in patients with juvenile idiopathic arthritis
Arthritis and Rheumatology
Long-Term Visual Outcome of Patients with Blau Syndrome
Ocular Immunology and Inflammation