Negative DNA supercoiling induces genome-wide Cas9 off-target activity

26 October 2023, 1.00 PM - 26 October 2023, 2.00 PM

David Rueda (Imperial College London)

C42 Biomedical Sciences Building

Hosted by the School of Biochemistry

Our team investigates the molecular mechanisms that regulate DNA/RNA metabolic processes involved in human diseases, such as cancer and neurodegeneration. To this aim, we develop and apply single-molecule approaches to image the structural dynamics of protein-nucleic acid complxes across scales (molecules to cells). 

Contact information

Enquires to Mark Dillingham

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