Title: Deciphering human antibody repertoires against the microbiome in health and disease.
Abstract: Our current conception of antibody repertoires is mostly based on DNA sequencing of the corresponding BCR sequences, whereas the actual antigens recognized are vastly unknown. My lab strives to unravel the functional capacity of these enormous immune repertoires targeting microbiota and to shed light on their role in different diseases contexts such as autoimmune diseases and cancer. We are leveraging a high throughput phage display system to screen for hundreds of thousands of antigens in parallel (Vogl et al., 2021, Nature Medicine).
Here, I will give an overview on the technology, recent applications to diseases, as well as unpublished work around the development of the immune system, and immunogenetics.
Biography: Thomas Vogl is an Austrian molecular biologist and immunologist whose work focuses on understanding how the human immune system interacts with the gut microbiome and how this relationship influences diseases. As a group leader at the Center for Cancer Research at the Medical University of Vienna, he combines experimental biology with computational approaches such as machine learning and bioinformatics to study complex immune responses.
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Microsoft Teams meeting
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