Title: Communicable disease meets non-communicable disease: opportunities for early prevention of cardiometabolic disease
Summary:
Infections are ubiquitous and repeated inflammatory stimuli across the life course, with the greatest burden falling in early life. Infection has been implicated in cardiovascular disease (CVD) for over 200 years, but the mechanisms are poorly understood. I will given an overview of the epidemiological evidence linking childhood infection and inflammation with CVD and metabolic disease, and discuss how infection and inflammation may contribute to the marked social gradient in CVD. I will also discuss emerging mechanistic data and opportunities for primordial and primary prevention.
Biography:
David Burgner is a paediatric infectious diseases clinician scientist. He completed his PhD on susceptibility to severe infection at Oxford and subsequently trained at Great Ormond Street Hospital and St Mary's Hospital/Imperial College, London. He was the first and only infectious diseases paediatrician in Western Australia from 2002 until 2010, when he relocated to Melbourne to join the Murdoch Children’s Research Institute where he leads the Inflammatory Origins research group within the Infection and Immunity Theme. He is a National Health and Medical Research Council (NHMRC) Investigator Grant awardee, an honorary Professorial Fellow at Melbourne and Monash Universities, and a paediatric infectious diseases consultant at the Royal Children's Hospital, Melbourne.
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