IEU Seminar: Chrissie Thirlwell
MRC Integrative Epidemiology Unit (IEU) Seminar Series
Title: "Breaking Bad" - my life in cancer genomics
Abstract and biography:
Chrissie has worked in the field of cancer genomics for 15 years. Most recently her research group has focused on integrated genomic and circulating free DNA analysis in neuroendocrine (NET) and other solid tumours. NETs have a very low background mutation rate and commonly harbor mutations in epigenetic machinery, her group has therefore focused on epigenetic analyses integrated with sequencing and transcriptome data. This work has led to a number of collaborations within the UK, the BROAD Institute and at Harvard, UCSF, Bern, Verona, Madrid and Uppsala Universities. Chrissie’s move to Exeter has enabled the opportunity to bring together her experience of cancer genomics and epigenetics with the wealth of experience in diabetes research. It is known that there is an increased risk of developing certain cancers including bowel and uterine in individuals with type 2 diabetes and obesity. Through forming collaborations between type 2 diabetes, obesity and colorectal cancer researchers and utilizing existing data and new data created through the 100,000 genomes project she plans to investigate the biological processes linking these conditions, ultimately leading to cancer prevention, earlier diagnosis, novel treatment strategies and improved outcomes.