MRC Integrative Epidemiology Unit (IEU) Seminar Series

Title: Thinking about time in the context of Mendelian randomization and epidemiology

Abstract: Mendelian randomization estimates the lifetime effect of exposure on an outcome but what, precisely, do we mean by “lifetime effect”? I will present a precise definition of the lifetime effect that is estimated by Mendelian randomization and discuss how it impacts the interpretation and validity of Mendelian randomization analyses. For example, single nucleotide polymorphisms with effects that vary with age present problems to valid estimation with Mendelian randomization. Even with this precise definition, however, understanding common epidemiologic concepts such as relevant exposure windows and treatment strategies is required to correctly interpret Mendelian randomization estimates.

Biography: Dr. Jeremy Labrecque is a Postdoctoral research fellow in the Causal Inference Group at Erasmus MC in Rotterdam, the Netherlands. He received his PhD in Epidemiology from McGill University for his work on the effect of conditional cash transfer programs on child health in Brazil. Currently, his work focuses on using formal causal inference to improve observational research in epidemiology with a focus on Mendelian randomization and target trial emulation.

All welcome