Dr Luca Lotta, Clinical Investigator, Aetiology of Diabetes and Related Metabolic Disorders Programme, Honorary Clinician, Addenbrooke's Hospital, Fellow of Wolfson Colege Cambridge

29 June 2017, 4.00 PM - 29 June 2017, 5.00 PM


 Thursday, 29th June, 2017

16.00 – 17.00 – OS6 SEMINAR ROOM – Oakfield House

 Luca Lotta

Clinical Investigator, Aetiology of Diabetes and Related
Metabolic Disorders Programme
Honorary Clinician, Addenbrooke’s Hospital
Fellow of Wolfson College Cambridge

 Using naturally occurring genetic variants to understand the mechanisms of metabolic disease



Large-scale genetic association studies have advanced knowledge about the genetic determinants of metabolic traits but this has not always translated into enhanced understanding of disease mechanisms or clinical progress. This talk will discuss the integrative use of genetic associations as models to understand the pathophysiology of metabolic disease and its cardiovascular complications.


Luca A. Lotta is a Clinical Investigator in the Aetiology of Diabetes and Related Metabolic Disorders programme, an Honorary Clinician at Addenbrooke’s Hospital and a Fellow of Wolfson College Cambridge.

Luca graduated in Medicine summa cum laude from the University of Milan (Italy), where he also obtained a PhD in Methodology of Clinical Research with work on the genetics of common thrombotic disorders. In the frame of his PhD coursework, he spent time as a Visiting Scientist at the Human Genome Sequencing Center, Baylor College of Medicine (USA), leading a research project on the application of targeted second-generation DNA-sequencing in early-onset cardiovascular and haemorrhagic diseases. He later obtained a second PhD from the University of Leiden (Netherlands) with a thesis on the pathophysiology of thrombotic thrombocytopenic purpura. In 2013, he moved to the MRC Epidemiology Unit (UK) in order to take on the discovery of biomarkers and causal mechanisms for the metabolic consequences of obesity in the frame of the EU-funded EMIF-Metabolic project.

Luca is author of several peer-reviewed scientific publications and a recipient of national and international awards, including the Bayer Hemophilia Award and the Raffaello De Biasi Award from the Italian Association of Haemophilia Centres.


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