Blood clots are a common and serious complication of cancer. To better understand who is at risk of this condition, researchers at the University of Bristol analysed data from more than 12,500 people recruited to the Genomics England 100,000 Genomes Project Cancer Programme.
They found that specific genetic changes (mutations) in the tumour DNA were associated with higher rates of blood clots. The study also identified potential interactions between inherited genetic risks and tumour mutations, providing new insights into why some people with cancer may develop blood clots.
This new animation, narrated by Clinical Academic Training Fellow Naomi Cornish, shares findings from this work. Thank you to all participants of the National Genomics Research Library, our PPIE contributors for their guidance, and Wellcome for funding this project.