Understanding and blocking resistance
Identifying what makes bacteria resistant to antibiotics and how it may be reversed or blocked.
Enzymology of resistance
Understanding the enzymology of antibiotic resistance to guide the development of new antibiotics and resistance inhibitor combinations
Inhibition of resistance
Understanding the biology of antimicrobial resistance to produce chemicals designed to inhibit resistance proteins thereby restoring the activity of failing antimicrobials
Control of antibiotic permeability
The bacterial envelope offers the first line of defence against antimicrobials. Understanding how bacteria control the entry and efflux of chemicals helps us to explain and possibly reverse antimicrobial drug resistance.