Press release issued: 23 April 2014
Neuroscientists have discovered a brain pathway that underlies the emotional behaviours critical for survival.
New research by the University of Bristol, published in the Journal of Physiology today [23 April], has identified a chain of neural connections which links central survival circuits to the spinal cord, causing the body to freeze when experiencing fear.
Understanding how these central neural pathways work is a fundamental step towards developing effective treatments for emotional disorders such as anxiety, panic attacks and phobias.
An important brain region responsible for how humans and animals respond to danger is known as the PAG (periaqueductal grey), and it can trigger responses such as freezing, a high heart rate, increase in blood pressure and the desire for flight or fight.
This latest research has discovered a brain pathway leading from the PAG to a highly localised part of the cerebellum, called the pyramis. The research went on to show that the pyramis is involved in generating freezing behaviour when central survival networks are activated during innate and learnt threatening situations.
The pyramis may therefore serve as an important point of convergence for different survival networks in order to react to an emotionally challenging situation.
Dr Stella Koutsikou, first author of the study and Research Associate in the School of Physiology and Pharmacology at the University of Bristol, said: “There is a growing consensus that understanding the neural circuits underlying fear behaviour is a fundamental step towards developing effective treatments for behavioural changes associated with emotional disorders.”
Professor Bridget Lumb, Professor of Systems Neuroscience, added: “Our work introduces the novel concept that the cerebellum is a promising target for therapeutic strategies to manage dysregulation of emotional states such as panic disorders and phobias.”
The researchers involved in this work are all members of Bristol Neuroscience which fosters interactions across one of the largest communities of neuroscientists in the UK.
Professor Richard Apps said: “This is a great example of how Bristol Neuroscience brings together expertise in different fields of neuroscience leading to exciting new insights into brain function.”
The research was funded by the the Biotechnology and Biological Sciences Research Council (BBSRC).
‘Neural substrates underlying fear-evoked freezing: the periaqueductal grey – cerebellar link’ by Stella Koutsikou, Jonathan J. Crook, Emma V. Earl, J. Lianne Leith, Thomas C. Watson, Bridget M. Lumb and Richard Apps (2014) in theJournal of Physiology doi:10.1113/jphysiol.2013.268714
About Bristol Neuroscience
Neuroscience is one of the key areas of research at the University of Bristol. Bristol has one of the largest concentrations of researchers engaged in neuroscience in the UK, many of whom are internationally recognised. In 2003 Bristol Neuroscience (BN) was established to enable all neuroscientists working in Bristol – both within the University and its partner hospitals across the city – to make full use of all available resources and expertise. BN runs numerous activities to encourage the dissemination of ideas, to create opportunities for interdisciplinary research, and to facilitate the pursuit of neuroscience to the highest possible standard. For further information on BN please see the Bristol Neuroscience website.
About the Biotechnology and Biological Sciences Research Council
The Biotechnology and Biological Sciences Research Council (BBSRC) invests in world-class bioscience research and training on behalf of the UK public. Our aim is to further scientific knowledge, to promote economic growth, wealth and job creation and to improve quality of life in the UK and beyond.
Funded by Government, and with an annual budget of around £467m (2012-2013), we support research and training in universities and strategically funded institutes. BBSRC research and the people we fund are helping society to meet major challenges, including food security, green energy and healthier, longer lives. Our investments underpin important UK economic sectors, such as farming, food, industrial biotechnology and pharmaceuticals.
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