Nuclear Magnetic Resonance in Families

Date:        6th March, 2014
Time:       16.00 - 17.00
Venue:     Room OS6 (Seminar Room), Oakfield House, Oakfield Grove

Abstract

GRAPHIC is a cohort of about 500 Leicestershire families, the members of which were genotyped and extensively phenotyped, particularly for blood pressure traits. Recently we have collaborated with the National Phenome Centre at Imperial to obtain nuclear magnetic resonance (NMR) spectra of the subjects’ urine and plasma. We are interested in whether these spectra are in influenced by genetics or whether they help predict the measured phenotypes. NMR spectra are known to be influenced by factors such as creatinine, lipoproteins and glucose but their analysis might also suggest new molecules that are worthy of further investigation. As the first stage in the examination of these data we have looked to see whether the NMR spectra show any within family correlations. The talk will describe the progress that we have made so far.

 Professor John Thompson

John Thompson is Professor of Genetic Epidemiology at the University of Leicester. John’s background is in biostatistics and originally he worked on methodological and applied issues in general epidemiology. For the last ten years he has worked almost exclusively on GWAS and other genetic epidemiological studies, with particular application to cardiovascular disease.


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