Every year, researchers in the School of Chemistry publish a large number of research papers in the peer-reviewed scientific literature. We highlight just a few of these below.
- Towards Ideality: The Synthesis of (+)-Kalkitoxin and (+)-Hydroxyphthioceranic Acid by Assembly-Line Synthesis.
The cover shows the stylized working of a molecular assembly line and conveys the overall process of how different groups can be added to a growing carbon chain with high fidelity and how these groups also control the overall shape of the molecule. The methodology has been applied to the fully stereocontrolled and short syntheses of kalkitoxin and 10-hydroxyphthioceranic acid.
- Multidimensional hierarchical self-assembly of amphiphilic cylindrical block comicelles
Self-assembly of molecular and block copolymer amphiphiles represents a well-established route to micelles with a wide variety of shapes and gel-like phases. This research demonstrates an analogous process, but on a longer length scale, in which amphiphilic P-H-P and H-P-H cylindrical triblock comicelles with hydrophobic (H) or polar (P) segments that are monodisperse in length are able to self-assemble side by side or end to end in nonsolvents for the central or terminal segments, respectively.
- Exploring How Protein Structures are Established
Experiments and calculations performed by Bristol scientists shed light on a controversial 40-year old theory of protein structure. There are many forces that hold together the three-dimensional, functional structures of proteins. Despite considerable effort, understanding of these forces is still quite rudimentary. The research from the Bristol team aimed to dissect out some of these forces by reducing the complexity of the problem.
- Studying the Dynamics of Reactions in Liquids
Chemists at the University of Bristol, in collaboration with colleagues at the Central Laser Facility at the Rutherford Appleton Laboratory (RAL) and Heriot-Watt University (HWU), can now follow chemical reactions in liquids with unprecedented, atomically resolved detail on sub-picosecond timescales (1 picosecond = 10-12s) – matching the time intervals between molecular collisions.