Cancer biology

Cancer biology in Bristol is rooted in a mechanistic approach to understanding how normal cellular processes become deregulated in disease.

Our emphasis is on defining, at molecular resolution, how signalling pathways, genome stability, DNA repair and cellular organisation contribute to transformation and tumour progression.

Our work spans biochemistry, structural biology and cell biology, and benefits from close integration with clinical research, allowing us to connect fundamental discovery with patient‑relevant questions.

Our overarching aim is to identify points of vulnerability in cancer cells that can be exploited therapeutically, and to develop more precise strategies for diagnosis and treatment.