Please note that these calculators are only applicable to patients who are:

• HIV-1 positive
• No previous antiretroviral therapy (ART)
• Age 16 years or older

There are two risk calculators:

• Risk calculated from start of ART
• Risk calculated from 6 months after start of ART, taking into account initial virological and immunological response

The first calculator estimates the probability of experiencing a new AIDS defining disease or death by the end of 1, 2, 3, 4 and 5 years after the patient starts antiretroviral therapy. It also estimates the probability of death from all causes (either HIV or non-HIV related) for up to five years after the start of therapy.

The second calculator estimates the probability of experiencing a new AIDS defining disease or death taking into account the initial response of the patient to ART as measured by their CD4 cell count and HIV-RNA viral load at 6 months after the start of ART. The probabilities are given for 1, 2, 3, 4 and 5 years after the time of the 6 month measurements. It also estimates the probability of death from all causes for up to five years after the time of the 6 month measure.