Our research

The ART Cohort Collaboration, which includes 21 cohort studies from Europe and North America, was established to estimate prognosis of HIV-1 positive, treatment naïve patients initiating highly active antiretroviral therapy (ART).

The first paper resulting from the collaboration was published in The Lancet on 13 July 2002. The database now includes information on over 100,000 patients and we regularly publish papers and contribute to major HIV conferences such as CROI and IAS. You can download our themes (Office document, 46kB) if you like.

A major success of the collaboration has been to develop risk calculators to estimate prognosis in the first 5 years of ART. We have also worked with the VACS cohort to validate their 'VACS Index', which uses detailed lab measurements, both HIV and non-HIV related to estimate prognosis. Click here for more information.

Our current research interests include:

  • analysis of risk factors for changing the first ART regimen and the effects of switching (Office document, 77kB) ART regimen on rates of AIDS and death (in collaboration with the HIV Causal Collaboration)
  • describing causes of death among HIV-positive individuals
  • comparing the effectiveness of initial ART regimen as seen in clinical trials (Office document, 93kB), with the effectiveness in observational cohorts
  • investigating reasons for heterogeneity (Office document, 56kB) in patient outcomes
  • prognosis for patients starting ART and comparisons with resource-poor settings
  • differences in mortality rates among treated patients according to geographical origin and ethnicity/race (Office document, 56kB)
  • differences in mortality rates among treated patients according to HIV viral subtype
  • comparisons of measures of adherence to ART across cohorts
  • investigating the impact of persistent low-level HIV viremia on virological outcome in treated HIV-infected patients
  • investigating optimal timing of ART initiation in patients with certain opportunistic infections

All projects are initially written up as a concept sheet and discussed by the ART-CC Executive Committee. Here is a document of approved concept sheets (Office document, 404kB) currently underway and here is a blank concept sheet (Office document, 42kB).

For all papers, writing committees (Office document, 57kB) are agreed, and all authors on the writing committee will have access to the paper at each stage of the article-writing process.

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