Dr Allen Goodship | School of Anatomy

Emeritus Professor

University of Bristol and Department of Medical Physics UCL

Honorary research contracts at the Royal National Orthopaedic Hospital (RNOH) NHS Trust and the Royal Veterinary College

Previously, Director of Institute of Orthopaedics and Musculoskeletal Science (IOMS), UCL and Head of Centre for Comparative and Clinical Anatomy University of Bristol

Past, President of the International Society for Fracture Repair and British Orthopaedic Research Society

Research Interests

My main interests are the influence of function on adaptation, repair and regeneration of skeletal tissues in the healthy, ageing, degenerate and diseased states; the clinical and commercial translation of this knowledge to the enhanced management of skeletal disorders. I have achieved significant advances in musculoskeletal research, in particular the factors inducing change in the biochemical and biomechanical properties of skeletal tissues. Recently, I have been involved in developing a novel application of Raman spectroscopy in determination of the chemical composition of bone matrix and association of bone matrix chemical fingerprints with specific bone disorders at an early state prior to overt clinical signs.

Recent Publications

Smith, J. O., Tayton, E. R., Khan, F., Aarvold, A., Cook, R. B., Goodship, A., . . . Oreffo, R. O. C. (2017). Large animal in vivo evaluation of a binary blend polymer scaffold for skeletal tissue-engineering strategies; translational issues. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 11 (4), 1065-1076. doi:10.1002/term.2007
Sowoidnich, K., Churchwell, J. H., Buckley, K., Goodship, A. E., Parker, A. W., & Matousek, P. (2017). Spatially offset Raman spectroscopy for photon migration studies in bones with different mineralization levels. ANALYST, 142 (17), 3219-3226. doi:10.1039/c7an00408g
Dickinson, S. C., Sutton, C. A., Brady, K., Salerno, A., Katopodi, T., Williams, R. L., . . . Hollander, A. P. (2017). The Wnt5a Receptor, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation. Stem cells (Dayton, Ohio). doi:10.1002/stem.2691
Sowoidnich, K., Churchwell, J. H., Buckley, K., Kerns, J. G., Goodship, A. E., Parker, A. W., & Matousek, P. (2016). Assessment of photon migration for subsurface probing in selected types of bone using Spatially Offset Raman Spectroscopy. BIOPHOTONICS: PHOTONIC SOLUTIONS FOR BETTER HEALTH CARE V, 9887. SPIE-INT SOC OPTICAL ENGINEERING. doi:10.1117/12.2227384
Bergström, I., Kerns, J. G., Törnqvist, A. E., Perdikouri, C., Mathavan, N., Koskela, A., . . . Windahl, S. H. (2016). Compressive loading of the murine tibia reveals site-specific micro-scale differences in adaptation and maturation rates of bone. Osteoporos Int. doi:10.1007/s00198-016-3846-6
Ranzoni, A. M., Corcelli, M., Hau, K. L., Kerns, J. G., Vanleene, M., Shefelbine, S., . . . Guillot, P. V. (2016). Counteracting bone fragility with human amniotic mesenchymal stem cells. Scientific Reports, 6, 39656. doi:10.1038/srep39656
Godoy, R. F., Coathup, M. J., Blunn, G. W., Alves, A. L. G., Robotti, P., & Goodship, A. E. (2016). Fast plasma sintering delivers functional graded materials components with macroporous structures and osseointegration properties. European Cells and Materials, 31, 250-263. doi:10.22203/eCM.v031a17
Kerns, J. G., Buckley, K., Churchwell, J., Parker, A. W., Matousek, P., & Goodship, A. E. (2016). Is the Collagen Primed for Mineralization in Specific Regions of the Turkey Tendon? An Investigation of the Protein-Mineral Interface Using Raman Spectroscopy. ANALYTICAL CHEMISTRY, 88 (3), 1559-1563. doi:10.1021/acs.analchem.5b00406
Sowoidnich, K., Churchwell, J. H., Buckley, K., Goodship, A. E., Parker, A. W., & Matousek, P. (2016). Photon migration of Raman signal in bone as measured with spatially offset Raman spectroscopy. JOURNAL OF RAMAN SPECTROSCOPY, 47 (2), 240-247. doi:10.1002/jrs.4781
Kallepitis, C., Autefage, H., Allen, F., Goodship, A. E., Jones, J. R., Blunn, G., & Stevens, M. M. (2016). Raman imaging analysis reveals native-like bone repair of defects induced by porous strontium-loaded bioactive glass. BIOMEDICAL VIBRATIONAL SPECTROSCOPY 2016: ADVANCES IN RESEARCH AND INDUSTRY, 9704. SPIE-INT SOC OPTICAL ENGINEERING. doi:10.1117/12.2212239
Whitehouse, M. R., Howells, N. R., Parry, M. C., Austin, E., Kafienah, W., Brady, K., . . . Hollander, A. P. (2016). Repair of Torn Avascular Meniscal Cartilage Using Undifferentiated Autologous Mesenchymal Stem Cells: From In Vitro Optimization to a First-in-Human Study. Stem Cells Transl Med. doi:10.1002/sctm.16-0199
Thorpe, C. T., McDermott, B. T., Goodship, A. E., Clegg, P. D., & Birch, H. L. (2015). Ageing does not result in a decline in cell synthetic activity in an injury prone tendon. Scandinavian Journal of Medicine & Science In Sports. doi:10.1111/sms.12500
Coathup, M. J., Pendegrass, C. P., Goodship, A. E., & Blunn, G. W. (2015). In Vivo Soft Tissue Models. In H. Simpson, P. Augut (Eds.), Experimental Research Methods in Orthopedics and Trauma (pp. 356-365). Thieme.
Hillam, R. A., Goodship, A. E., & Skerry, T. M. (2015). Peak strain magnitudes and rates in the tibia exceed greatly those in the skull: An in vivo study in a human subject. Journal of Biomechanics, 48 (12), 3292-3298. doi:10.1016/j.jbiomech.2015.06.021
Kerns, J. G., Buckley, K., Gikas, P. D., Birch, H. L., McCarthy, I. D., Keen, R., . . . Goodship, A. E. (2015). Raman spectroscopy reveals evidence for early bone changes in osteoarthritis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 96 (2), A3.
Sowoidnich, K., Churchwell, J. H., Buckley, K., Kerns, J. G., Goodship, A. E., Parker, A. W., & Matousek, P. (2015). Spatially Offset Raman Spectroscopy for photon migration investigations in long bone. NOVEL BIOPHOTONICS TECHNIQUES AND APPLICATIONS III, 9540. SPIE-INT SOC OPTICAL ENGINEERING. doi:10.1117/12.2183632
Tayton, E., Purcell, M., Smith, J. O., Lanham, S., Howdle, S. M., Shakesheff, K. M., . . . Oreffo, R. O. C. (2015). The scale-up of a tissue engineered porous hydroxyapatite polymer composite scaffold for use in bone repair: An ovine femoral condyle defect study. Journal of Biomedical Materials Research - Part A, 103 (4), 1346-1356. doi:10.1002/jbm.a.35279
Kerns, J. G., Buckley, K., Parker, A. W., Birch, H. L., Matousek, P., Hildred, A., & Goodship, A. E. (2015). The use of laser spectroscopy to investigate bone disease in King Henry VIII's sailors. Journal of Archaeological Science, 53, 516-520. doi:10.1016/j.jas.2014.11.013

Awards

I have received the following awards and prizes: Animal Health Trust’s Scheering Plough Animal Health Veterinary Achievement Award, Equine Veterinary Journal Open Award, Clinical Biomechanics Award from the European Society of Biomechanics, and shares the 2006 Meggers award from the Society for Applied Spectroscopy (SAS). Previously I was a member of the EPSRC peer review college. I was named Inventor on a number of patents resulting from the translational research and actively involved in two university spin-out companies, Stanmore Implants Worldwide (www.stanmoreimplants.com) and VetCell (www.vetcell.com).