Unit name | Coronary Artery Disease |
---|---|
Unit code | SOCSM0019 |
Credit points | 20 |
Level of study | M/7 |
Teaching block(s) |
Teaching Block 1 (weeks 1 - 12) |
Unit director | Dr. Bond |
Open unit status | Not open |
Pre-requisites |
NONE |
Co-requisites |
NONE |
School/department | Bristol Medical School |
Faculty | Faculty of Health Sciences |
This unit will introduce the clinical problem of cardiovascular disease. It will provide an overview of the methods currently utilised for patient diagnosis and assessment of disease severity (from GP to clinic), such as ECG, angiogram, imaging (IVUS, PET) and biomarkers. The unit will provide a detailed overview of the underlying pathobiologies including atherosclerosis (endothelial cell dysfunction, inflammation, smooth muscle cell proliferation, migration and apoptosis, plaque rupture, thrombosis and vessel occlusion). Furthermore, it will discuss the impact of genomics on cardiovascular disease, common risk factors (including hypercholesterolemia, hypertension, diabetes, smoking), and its epidemiology. Finally, this unit will outline the currently used drug and interventional treatments for cardiovascular disease.
Coursework (contributing a total of 60% to the unit) consisting of:
Please note that students will be given feedback on all coursework assessment.
Written exam (contributing a total of 40% to the unit) consisting of:
The overall pass-mark for the unit will be 50%. However, students will be required to reach a minimum standard in both their coursework and their written exam; only 5% compensation between the total coursework element and the total exam element will be allowed.
Fishbein, MC, The vulnerable and unstable atherosclerotic plaque.Cardiovascular Pathology;19(1):6-11.
Farb, A, AP Burke, AL Tang, Y Liang, P Mannan, J Smialek, R Virmani, Coronary Plaque Erosion Without Rupture Into a Lipid Core : A Frequent Cause of Coronary Thrombosis in Sudden Coronary Death. Circulation, 1996;93(7):1354-1363.
Alsheikh-Ali, AA, GD Kitsios, EM Balk, J Lau, S Ip, The Vulnerable Atherosclerotic Plaque: Scope of the Literature. Annals of Internal Medicine, 2010;153(6):387-W149.
Libby, P, Inflammation in atherosclerosis. Nature, 2002;420:868-874.
Libby, P, Y Okamoto, VZ Rocha, E Folco, Inflammation in Atherosclerosis: Transition From Theory to Practice. Circulation Journal, 2010;74(2):213-220.
Toutouzas, K, M Drakopoulou, I Skoumas, C Stefanadis, Advancing therapy for hypercholesterolemia. Expert Opinion on Pharmacotherapy, 2010;11(10):1659-1672.
Essential and recommended reading as indicated by each lecturer