Influencing cancer drug development programmes
Collaboration between researchers and the pharmaceutical industry has led to major investment in cancer drug discovery programmes that target inhibitors in transporter proteins.
Altering cellular function of immune system could help target allergies
Peanut allergy has long-term consequences and potentially life threatening effects, but there is no clinically available cure. A cellular and molecular could provide new clues.
Discovery of a bacterial protein's unusual properties have given rise to a novel drug for the treatment of inflammatory diseases which affect hundreds of millions of people globally.
Genetic mapping improves understanding of osteoarthritis
Using multi-disciplinary techniques to map the development of osteoarthritis in zebrafish genes allows a greater understanding of joint deterioration in humans.
New diagnostic tests for rare kidney disease
Red blood cell research identifies new tests for distal renal tubular acidosis (dRTA) - a potentially fatal kidney disease that can be treated with a spoonful of bicarbonate.
Combatting antimicrobial resistance
Microbiologists at the University of Bristol are investigating exactly why current drugs are not working in an attempt to reverse this trend before it’s too late.
Improving accuracy of diagnosis for childhood leukaemia
New cell analysis procedures have led to improved diagnostic techniques and national standards for cell processing.
Predicting IVF success with greater accuracy
A free, easy-to-use online calculator is the most accurate tool for predicting live birth outcomes for couples considering IVF treatment.
Helping prevent and treat bowel cancer
Identifying apoptosis (cell suicide) as a plausible scientific mechanism for how a high fibre diet and aspirin may prevent and treat bowel cancer.
Understanding the building blocks of cancer gives vital clues to treatment
Research into the cellular and molecular basis of cancer has discovered how controlling the protein activity in cells could help treat colorectal cancer.
Search for new cancer biomarker propelled by detailed exploration of cell structures
Advances in science, diagnosis and treatment mean that more people than ever before are surviving cancer. But with an increase in survival rates comes an increase in the possibility that for some people, cancer will recur later in life. This presents a continuing challenge for cancer research – biomedical scientists at Bristol University are finding new ways to find a solution.
Landmark discoveries that could dramatically improve cardiac care
Research into the regulation of calcium in cardiac muscle cells uses computer models to further understanding of molecular control and develop new ways to treat heart failure.
Neurotransmitters may be behind debilitating headaches
Motivation, addiction, sleep, high blood pressure – one family of neurones is implicated and if researchers at the University of Bristol hypothesise correctly, migraines could also be added to that list.
Revealing the mechanism behind sensitive tooth pain has helped leading brands develop better desensitising toothpastes that provide relief for pain sufferers.
Reducing heart attack tissue damage
Pharmaceutical companies have shifted their focus for cardioprotective drug development based on research conducted at the University of Bristol.
Schizophrenia linked to functional disconnections in the brain
Attempts to understand schizophrenia and its diverse symptoms have taken researchers and psychiatrists on a journey throughout the brain.