Prostate Testing for Cancer and Treatment (ProtecT)

Prostate cancer is a serious health problem. There are 35,000 new cases every year in the UK, and around 10,000 deaths. The ProtecT study is a research project taking place in nine parts of the UK.

ProtecT study findings

Please see the two recent updates below. A link to an academic paper by ProtecT researchers concerning decision making for localised prostate cancer patients and an interview with them about it.

The first major results from the ProtecT study were published on September 15th, 2016. All participants were sent a copy of our results newsletter. The results were widely reported in the newspapers, TV, radio and on-line. These first results present the outcomes of the men who agreed to be randomised to the active monitoring group or surgery group or radiotherapy group. The groups are compared up to the end of 2015 - over an average of 10 years.  

Results published in the New England Journal of Medicine show that all three treatments result in similar, and very low, rates of death from prostate cancer. Surgery and radiotherapy reduce the risk of cancer progression over time compared with active monitoring, but cause more unpleasant side-effects.

More research is needed to identify the cancers that will progress or spread, and those that do not. Longer follow up is needed to find out how survival, progression and spread of cancer, and quality of life will change over the next 5 to 10 years.

Recent newsletter and publications:

ProtecT study centres

  • Bristol Southmead Hospital
    Lead Urologist: Mr Ed Rowe
  • Newcastle Freeman Hospital
    Lead Urologist: Mr Edgar Paez
  • Sheffield Royal Hallamshire Hospital
    Lead Urologist: Prof Derek Rosario
  • Birmingham Queen Elizabeth Hospital
    Lead Urologist: Mr Keval Patel
  • Cardiff University Hospital of Wales
    Lead Urologist: Owen Hughes
  • Edinburgh Western General Hospital
    Lead Urologist: Mr Daniel Good
  • Cambridge Addenbrookes Hospital
    Lead Urologist: Prof Vincent Gnanapragasam
  • Leicester Leicester General Hospital
    Lead Urologist: Mr John Beatty
  • Leeds St James Hospital
    Lead Urologist: Mr Alan Paul

About the study

The aim of the ProtecT study is to find out the best ways of treating prostate cancer.

Read more about the study

Potential collaborators

We welcome collaboration from potential investigators carrying out studies in the field of urological research.

Read more about collaborating


The ProtecT Study
Population Health Sciences
University of Bristol
Canynge Hall
39 Whatley Road
Bristol, BS8 2PS
United Kingdom

International Standard Randomised Controlled Trial Number: ISRCTN20141297

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