
Dr Wael Kafienah
B.Sc., Ph.D.
Current positions
Associate Professor in Regenerative Medicine
School of Cellular and Molecular Medicine
Contact
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Biography
Dr Wael Kafienah is Associate Professor in Regenerative Medicine at the School of Biochemistry and Cellular and Molecular Medicine, University of Bristol, UK. He is member of ‘Regenerative Medicine and Stem Cell Therapies’ theme in the School. He graduated with a First Class Honours in Biomedical Sciences from the University of Ulster, Northern Ireland, and awarded the prestigious Versus Arthritis UK studentship to study PhD in cartilage metabolism at the University of Sheffield, UK. He worked as postdoctoral scientist at the University of Sheffield and Bristol with Prof. Anthony Hollander and was awarded a Novartis Foundation Fellowship at Prof. Arnold Caplan lab in Case Western Reserve University, Cleveland, USA. Upon returning to the UK he established a programme of work focusing on using stem cells and tissue engineering for the treatment of osteoarthritis and traumatic injury of the joint.
Dr Kafienah has been involved in translational research for over 20 years. He authored several impactful research articles on the use of nasal chondrocytes in tissue engineering, gene therapy to protect cartilage implants, repair of torn meniscus and scale-up of engineered cartilage using OA patient stem cells. More recently, he has been developing technologies to improve cartilage engineering outcomes using pluripotent stem cells and cellular reprogramming. His work has been funded by grants from the Medical Research Council, UK, Innovate UK, the European Union and several international and UK charities. Dr Kafienah is the author of several patents that led to co-founding of start-up companies including Azellon Therapeutics Ltd and Chondrogenix Ltd.
Dr Kafienah is a Fellow of the International Cartilage Repair and Joint Preservation Society (ICRS). He was the Co-Chair of the Scientific Programme Committee for the 17th World Congress ICRS, Sitges-Barcelona 2023.
Dr Kafienah has been involved in translational research for over 20 years. He authored several impactful research articles on the use of nasal chondrocytes in tissue engineering, gene therapy to protect cartilage implants, repair of torn meniscus and scale-up of engineered cartilage using OA patient stem cells. More recently, he has been developing technologies to improve cartilage engineering outcomes using pluripotent stem cells and cellular reprogramming. His work has been funded by grants from the Medical Research Council, UK, Innovate UK, the European Union and several international and UK charities. Dr Kafienah is the author of several patents that led to co-founding of start-up companies including Azellon Therapeutics Ltd and Chondrogenix Ltd.
Dr Kafienah is a Fellow of the International Cartilage Repair and Joint Preservation Society (ICRS). He was the Co-Chair of the Scientific Programme Committee for the 17th World Congress ICRS, Sitges-Barcelona 2023.
Research interests
- Cartilage tissue engineering using adult and pluripotent stem cells
- Novel biomaterials for tissue engineering and drug delivery
- Endogenous repair of damaged cartilage
- Stem cell interactions in infectious diseases
- Pharmacological regulation of adult and pluripotent stem cells for cartilage repair
Projects and supervisions
Research projects
A preclinical model for the treatment of osteoarthritis using chondrogenic human induced pluripotent stem cells
Principal Investigator
Managing organisational unit
School of Cellular and Molecular MedicineDates
01/01/2017 to 31/08/2017
Thesis supervisions
Stem Cell Membrane Re-Engineering for Adhesion to the Extracellular Matrix
Supervisors
Studies in chondrogenic cellular reprogramming
Supervisors
The role of stem cells in SARS-CoV-2 infection
Supervisors
Investigation of the metabolism of ecdysteroids and their human physiological effects
Supervisors
Novel immunoassay for human erythropoietin using camelid antibodies
Supervisors
Strategies for improving the chondrogenic differentiation of human induced pluripotent stem cells for cartilage therapy
Supervisors
The role of transforming growth factor beta superfamily in chondrogenic stem cells
Supervisors
Interaction between immune cells phenotype and the microbiome in B cells immunodeficiency diseases
Supervisors
Investigation of the molecular mechanisms of human mesenchymal stem cells and S. aureus interactions in osteomyelitis
Supervisors
Publications
Recent publications
27/06/2022Intravascular administration of soluble SARS-CoV-2 Spike protein triggers non-infective heart and lung inflammation and vascular pericytes rarefaction in healthy mice
European Heart Journal Supplements
An artificial membrane binding protein-polymer surfactant nanocomplex facilitates stem cell adhesion to the cartilage extracellular matrix
Biomaterials
Chondroinduction of Mesenchymal Stem Cells on Cellulose-Silk Composite nanofibrous Substrates
Frontiers in Bioengineering and Biotechnology
Bioreactor manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies
Cell Proliferation
Effects of Low-Frequency Electromagnetic Fields on Chondrocytes in Short-Term Cultures
Cyprus Journal of Medical Sciences