Dr Thom Sharp
PhD, BSc
Current positions
Associate Professor
School of Biochemistry
Contact
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Research interests
We use a combination of protein engineering, DNA nanotechnology, synthetic biology, super-resolution light microscopy and high-resolution cryoEM to investigate immune system activation.
Projects and supervisions
Research projects
Targeting C-reactive protein using structure-guided drug design for therapeutic gain
Principal Investigator
Managing organisational unit
School of BiochemistryDates
01/08/2024 to 31/07/2027
Targeting C-reactive protein using structure-guided drug design for therapeutic gain
Principal Investigator
Managing organisational unit
School of BiochemistryDates
01/08/2024 to 31/07/2027
Publications
Recent publications
07/05/2024Design and Synthesis of DNA Origami Nanostructures to Control TNF Receptor Activation
Imaging Cell Signalling
Imaging intracellular components in situ using super-resolution cryo-correlative light and electron microscopy
Correlative Light and Electron Microscopy V
Building a super-resolution fluorescence cryomicroscope
Methods in Cell Biology
DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation
Journal of the American Chemical Society
Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation
Journal of Immunology
Related people
Professor David Sheppard
Professor of Physiology
School of Physiology, Pharmacology & Neuroscience
Professor Dek Woolfson
Professor of Chemistry and Biochemistry
School of Chemistry
Professor Paul Verkade
Professor of Bioimaging
School of Biochemistry
Dr Aimee Boyle
Research Fellow
School of Chemistry
Dr Richard Sessions
Honorary Senior Research Fellow
School of Biochemistry