Dr Thom Sharp
PhD, BSc
Current positions
Associate Professor
School of Biochemistry
Contact
Press and media
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Research interests
We use a combination of structural and synthetic biology to understand and control the human immune system.
Read more about our research at the Sharp lab website: https://sharplab.uk/
Projects and supervisions
Research projects
Targeting C-reactive protein using structure-guided drug design for therapeutic gain
Principal Investigator
Managing organisational unit
School of BiochemistryDates
01/08/2024 to 31/07/2027
Targeting C-reactive protein using structure-guided drug design for therapeutic gain
Principal Investigator
Managing organisational unit
School of BiochemistryDates
01/08/2024 to 31/07/2027
Publications
Recent publications
24/06/2025Polyalanine Expansion in PABPN1 Alters the Structure and Dynamics of Its Nuclear Aggregates in Differentiated Muscle Cells
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Inducing Cancer Cell Killing Using DNA Nanostructure-Mediated Superclustering of Death Receptors
Nano Letters
Design and Synthesis of DNA Origami Nanostructures to Control TNF Receptor Activation
Imaging Cell Signalling
Imaging intracellular components in situ using super-resolution cryo-correlative light and electron microscopy
Correlative Light and Electron Microscopy V
Building a super-resolution fluorescence cryomicroscope
Methods in Cell Biology
Related people
Professor David Sheppard
Professor of Physiology
School of Physiology, Pharmacology & Neuroscience
Professor Dek Woolfson
Professor of Chemistry and Biochemistry
School of Chemistry
Professor Paul Verkade
Professor of Bioimaging
School of Biochemistry
Dr Aimee Boyle
Research Fellow
School of Chemistry
Dr Richard Sessions
Honorary Senior Research Fellow
School of Biochemistry