Dr Thom Sharp
PhD, BSc
Current positions
Associate Professor
School of Biochemistry
Contact
Press and media
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Research interests
We use a combination of structural and synthetic biology to understand and control the human immune system.
Read more about our research at the Sharp lab website: https://sharplab.uk/
Projects and supervisions
Research projects
Targeting C-reactive protein using structure-guided drug design for therapeutic gain
Principal Investigator
Managing organisational unit
School of BiochemistryDates
01/08/2024 to 31/07/2027
Targeting C-reactive protein using structure-guided drug design for therapeutic gain
Principal Investigator
Managing organisational unit
School of BiochemistryDates
01/08/2024 to 31/07/2027
Publications
Recent publications
18/12/2025Cell-surface RNA forms ternary complex with RNA-binding proteins and heparan sulfate to recruit immune receptors
Molecular Cell
Dual-colour super-resolution cryoCLEM in mammalian cells using the fluorescent proteins rsTagRFP and rsEGFP2
Journal of Structural Biology
Modulation of immunoglobulin G oligomerization by variable domain glycans
PNAS Nexus
Polyalanine Expansion in PABPN1 Alters the Structure and Dynamics of Its Nuclear Aggregates in Differentiated Muscle Cells
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding
Communications Biology
Related people
Mrs Judith Mantell
Technical Specialist in Electron Microscopy Research
School of Biochemistry
Professor Dek Woolfson
Professor of Chemistry and Biochemistry
School of Chemistry
Professor Paul Verkade
Professor of Bioimaging
School of Biochemistry
Dr Aimee Boyle
Research Fellow
School of Chemistry
Dr Richard Sessions
Honorary Senior Research Fellow
School of Biochemistry