Haemotropic mycoplasma infections

I am involved in the investigation of haemotropic mycoplasmas (haemoplasmas), which are bacterial agents that can induce haemolytic anaemia in a range of host species.  Most of our studies centre on the feline haemoplasmas but we have carried out research on a range of haemoplasma species including canine, rodent and human species. Our research has focused on: the development of novel polymerase chain reaction (PCR) assays and serological tests to detect haemoplasma infection, the phylogeny of haemoplasmas, the pathogenesis of the haemoplasma-associated anaemia and induced immunity, and genomic studies that have resulted in the first complete haemoplasma genomic sequence (Mycoplasma haemofelis).  We have also investigated in vitro methods of haemoplasma cultivation and protective immunity.

Feline coronavirus (FCoV) infections

Feline coronavirus (FCoV) infection is very common in cats and can sometimes lead to the serious disease of feline infectious peritonitis (FIP). This was a common cause of death in young cats although effective antivirals such as GS-441524 are now often used to successfully treat FIP. Our research in this field is to ultimately help the diagnosis, prevention and treatment of this disease.  Research involves the development of reliable diagnostic tests for the definitive diagnosis of FIP, evaluating treatment, deriving genome sequences of field coronavirus isolates, identification of feline coronavirus host receptors and the development of a so-called “reverse genetic” system for feline coronaviruses. The reverse genetic systemic involves constructing a copy of the virus in a form that can be changed in a specific way. This is a complex process but it will be of immense value in our basic research and, in the longer term, can be used to produce vaccines against FIP.