Dr Sam Hayward
BMedSci - 1st class honours, MBChB, MRCP
Contact
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Research interests
I am a kidney doctor with an interest in genomics and molecular epidemiology. My PhD research focuses on people with Nephrotic syndrome; I am utilising machine learning to interrogate the genetic and epigenetic profiles of people with this kidney disorder to improve our understanding of disease drivers and our ability to predict prognosis.
Projects and supervisions
Research projects
The role of DNA methylation in stratifying and understanding paediatric nephrotic syndrome - a combined bioinformatics and CRISPR-cas9 approach
Principal Investigator
Description
PhD fellowship to investigate epigenetic differences between Nephrotic Syndrome subgroups.Managing organisational unit
Bristol Medical SchoolDates
01/09/2021 to 01/07/2025
The burden of polypharmacy in older people with advanced chronic kidney disease
Role
Co-Investigator
Description
Exploring the prevalence of polypharmacy and the changes in prescribing prior to death in older people with advanced chronic kidney disease.Managing organisational unit
Bristol Medical SchoolDates
01/08/2017 to 22/09/2023
Publications
Selected publications
10/02/2023Epigenetic Mechanisms and Nephrotic Syndrome
Biomedicines
What is circulating factor disease and how is it currently explained?
Pediatric Nephrology
International prescribing patterns and polypharmacy in older people with advanced chronic kidney disease
Nephrology Dialysis Transplantation
Kidney Failure Prediction Models
Journal of the American Society of Nephrology
DNA methylation and response to steroids in children with nephrotic syndrome
57th ERA-EDTA Congress Abstracts
Recent publications
21/01/2025A novel, dominant disease mechanism of distal renal tubular acidosis with specific variants in ATP6V1B1
Nephrology Dialysis Transplantation
Cardiometabolic protein expression levels and pathways associated with kidney function decline in older European adults with advanced kidney disease
Clinical Kidney Journal
Prescribing patterns in older people with advanced chronic kidney disease towards the end of life
Clinical Kidney Journal
Protein Biomarkers and Major Cardiovascular Events in Older People With Advanced CKD
Kidney Medicine
A novel likely pathogenic CLCN5 variant in Dent’s disease
BMC Nephrology
Thesis
The role of DNA methylation in stratifying and understanding nephrotic syndrome
Supervisors
Award date
13/05/2025
Related people
Professor Moin Saleem
Professor
Bristol Medical School (THS)
Professor Fergus Caskey
Professor of Renal Medicine
Bristol Medical School (PHS)
Professor Penny Whiting
Professor of Clinical Epidemiology
Bristol Medical School (PHS)
Dr Matthew Suderman
Associate Professor in Molecular Epidemiology
Bristol Medical School (PHS)
Dr Barny Hole
Honorary Research Associate
Bristol Medical School (PHS)