Professor Matthew Crump
B.Sc., Ph.D.(Bristol)
Current positions
Professor of NMR and Structural Biology
School of Chemistry
Contact
Press and media
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Research interests
Group webpages can be found here! This has a more up to date list of publications than I can ever get the Bristol system to log!
My group's work has centred around the use of nuclear magnetic resonance spectroscopy to study protein structure and function. The most high profile of these are based in areas such as cancer, antibiotics and structure aided drug design that are of central importance to the well being of today's society.
A major highlight of our recent work has been the solution NMR structure of the domain 11 from the Insulin Growth factor receptor 2 and its interaction with IGF2. This milestone work has paved the way for CRUK and CRT funding (with Prof. Bass Hassan, University of Oxford) and it is an important step along the way to developing a therapeutic receptor to be used in the treatment of several different cancers. This work is currently the major theme within my laboratory alongside the application of NMR for screening potential small ligands for proteins of pharmaceutical interest (funded by UCB).
Finally we increasingly use X-ray crystallography for the structure determination of larger proteins and we have and have over ten collaborative NMR/X-ray projects running in the laboratory (funded by BBSRC, MRC and EPSRC).
Professor Crump is a supervisor in the EPSRC Centre for Doctoral Training in Chemical Synthesis
Projects and supervisions
Research projects
New tools for elucidating natural product biosynthesis in-situ at atomic resolution
Principal Investigator
Managing organisational unit
School of ChemistryDates
01/09/2022 to 31/08/2025
New tools for elucidating natural product biosynthesis in-situ at atomic resolution
Principal Investigator
Managing organisational unit
School of ChemistryDates
01/09/2022 to 31/08/2025
A globally unique 19F, 13C, 15N NMR system to enable frontier bioscience
Principal Investigator
Managing organisational unit
School of ChemistryDates
15/08/2021 to 14/08/2022
Tapping the MycoDiverse Library with state of the art NMR - BIV
Principal Investigator
Managing organisational unit
School of ChemistryDates
01/07/2018 to 31/12/2018
IGF2-TRAP development; preparation for funding applications for a first in man trial
Principal Investigator
Managing organisational unit
School of ChemistryDates
01/09/2016 to 31/08/2017
Thesis supervisions
Biosynthetic Studies on Kalimantacin Antibiotics
Supervisors
Fatty acid construction within the biosynthesis of the polyketide antibiotic mupirocin
Supervisors
Synthetic and biosynthetic studies on polyketide natural products
Supervisors
Urea Based Synthetic Lectins
Supervisors
Mechanisms for the Generation of Structural Diversity in Polyketide Biosynthesis
Supervisors
Structural characterisation of a carbohydrate binding domain of the human cation-independent mannose 6-phosphate/ IGF2 receptor
Supervisors
The molecular basis of HicA dependent binding of HicB to DNA
Supervisors
Synthetic and biosynthetic studies on the ambruticins
Supervisors
From peptide oligomers to single-chain proteins
Supervisors
Presentation of a new method of producing big Insulin-like Growth Factor 2, validation of this method and research into a new antibody-free quantification method for Insulin-like growth factor 2
Supervisors
Publications
Selected publications
01/11/2013A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis
Nature Chemical Biology
An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science
Recent publications
12/03/2024Combining Total Synthesis and Genetic Engineering to Probe Dihydropyran Formation in Ambruticin Biosynthesis
Chemical Science
An expandable, modular de novo protein platform for precision redox engineering
Proceedings of the National Academy of Sciences of the United States of America
An N-terminal alpha-synuclein fragment binds lipid vesicles to modulate lipid-induced aggregation
Cell Reports Physical Science
Polyketide Synthase-Mediated O-Methyloxime Formation in the Biosynthesis of the Oximidine Anticancer Agents
Angewandte Chemie - International Edition
Structure and Function of the α-Hydroxylation Bimodule of the Mupirocin Polyketide Synthase
Angewandte Chemie - International Edition