
Professor Kathleen Gillespie
B.Sc.(Galway), Ph.D.(Wales)
Current positions
Professor of Molecular Medicine
Bristol Medical School (THS)
Contact
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Research interests
Kathleen has led Diabetes and Metabolism since November 2014, when she also became Chief Investigator of the Bart's Oxford (BOX) family study of type 1 diabetes. She is a molecular biologist interested in the mechanisms underlying autoimmunity. Her current projects include
- the first natural history study of risk of type 1 diabetes in the general population adults (Type 1 diabetes risk in adults - T1DRA)
- an international collaborative study of why some children develop type 1 diabetes in the first few years of life while others who have the markers of ongoing islet autoimmunity are not diagnosed until adulthood
- examining longitudinal genetic and islet autoantibody data from the BOX study to predict outcomes
- developing new biomarker assays
- understanding why children with Down's syndrome are at increased risk of autoimmunity
Current funding has been provided by the Helmsley Charitable Trust, NIDDK, Diabetes UK, the Juvenile Diabetes Research Foundation International and the European Foundation for the study of diabetes.
Projects and supervisions
Thesis supervisions
Analysing the genetic, immunological and pancreatic characteristics of type 1 diabetes to gain new insights into the aetiology of the disease
Supervisors
Feeding and Autoimmunity in Children with Down’s Syndrome Evaluation Study (FADES)
Supervisors
End of Life Care in Gynaecological Cancer
Supervisors
Beta cell loss in autoimmune diabetes
Supervisors
The natural history of the autoimmune response to zinc transporter 8 (ZnT8) in type 1 diabetes
Supervisors
Developing novel luminescence methods for measuring antibodies
Supervisors
Down syndrome and Diabetes - Insights into rapid progression to Type 1 Diabetes
Supervisors
Type 1 Diabetes Biomarkers Including Trypsinogen
Supervisors
The changing frequency of Type 1 diabetes-associated genes over time
Supervisors
Publications
Recent publications
22/01/2026Improved prediction of symptomatic type 1 diabetes using a luciferase-based assay to measure (pro)insulin autoantibodies
Diabetic Medicine
Genetic risk-targeted islet autoantibody screening for presymptomatic type 1 diabetes in adults
Lancet Diabetes and Endocrinology
UK best practice recommendations for children and young people <18 years with pre‐stage 3 type 1 diabetes, on behalf of the British Society for Paediatric Endocrinology and Diabetes ( BSPED )
Diabetic Medicine
A novel, high-performance, low-volume, rapid luciferase immunoprecipitation system (LIPS) assay to detect autoantibodies to zinc transporter 8
Clinical and Experimental Immunology
Autoantibodies to truncated GAD(96-585) antigen stratify risk of early insulin requirement in adult-onset diabetes
Diabetes



