
Miss Claire Williams
PhD
Current positions
Senior Research Associate
Bristol Medical School
Contact
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Research interests
Senior Research Associate based at the University of Bristol with 12 years of research experience in a dynamic research group. My work primarily focuses on developing biomarker assays and utilizing islet autoantibodies and other biomarkers to predict, classify, and understand autoimmunity in type 1 diabetes and related autoimmunity. I am enthusiastic and passionate about translational bench-to-bedside research with verifiable impact to health outcomes. To date, this is evidenced through my publications of my clinical collaborations to investigate insulin autoimmine syndrome and my ongoing research collaboration in developing diagnostic assays.
My research interests and current projects and collaborations include:
- Characterising type 1 diabetes in under-represented populations such as Sub-Saharan Africa.
- Characterising type 1 diabetes across the age spectrum - clear differences are increasingly described in childhood-onset and adulthood-onset type 1 diabetes.
- The natural history of type 1 diabetes in individuals with familal history of type 1 diabetes (~15% of cases) and in individuals without familal history of type 1 diabetes (85%) through family cohorts and general population screening studies.
- Identifying and characterising novel biomarkers (e.g., exocrine and immune cell) to inform the variable progression rate from identification of autoimmune biomarkers to the development of clinical type 1 diabetes.
- Develop new biomarker assays that can inform/refine risk prediction modelling of clinical onset and response to therapy (e.g., immunotherapies).
Projects and supervisions
Research projects
Examination of pancreatic exocrine function/mass after type 1 diabetes diagnosis
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/06/2023 to 31/05/2024
The natural history of the autoimmune response to zinc transporter 8 in type 1 diabetes (PhD; Diabetes UK funded)
Principal Investigator
Managing organisational unit
Bristol Medical SchoolDates
02/10/2017 to 10/10/2021
Thesis supervisions
Publications
Recent publications
01/08/2026Improved prediction of symptomatic type 1 diabetes using a luciferase-based assay to measure (pro)insulin autoantibodies
Diabetic Medicine
Relative maternal protection against type 1 diabetes: A combined analysis of 5 observational studies
The Journal of Clinical Endocrinology & Metabolism
The C-terminal cysteines in zinc transporter 8 (ZnT8) form an independent epitope for autoantibody binding in newly diagnosed type 1 diabetes: Diabetes UK Professional Conference 2021
Clinical and Experimental Immunology
In response to comment on improved prediction of symptomatic type 1 diabetes using a luciferase-based assay to measure (pro) insulin autoantibodies
Diabetic Medicine
A novel, high-performance, low-volume, rapid luciferase immunoprecipitation system (LIPS) assay to detect autoantibodies to zinc transporter 8
Clinical and Experimental Immunology
Thesis
The natural history of the autoimmune response to zinc transporter 8 (ZnT8) in type 1 diabetes
Supervisors
Award date
25/01/2022


