Professor Jennifer McManus
BSc, PhD
Expertise
I am a soft -matter scientist interested in the self-assembly of biological macromolecules. My research aims to understand how inter-molecular protein interactions direct protein assembly to form crystals, gels and demixed liquids
Current positions
Head of School
School of PhysicsProfessor and Head of School of Physics
School of Physics
Contact
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Biography
I completed my BSc and PhD degrees in Chemistry at University College Dublin working on the assembly and structure of non-cytotoxic DNA - lipid complexes for use in non-viral gene delivery. During my PhD, I spent 7 months at the Max Planck Insitute for Polymer Research in Mainz, Germany, where I learned to use small-angle x-ray scattering to characterise the complexes. Following my PhD, I changed my research topic and became interested in protein phase diagrams and protein assembly as postdoctoral researcher in Switzerland and at the Massachusetts Institute of Technology, in the group of Prof. George Benedek. After almost 4 years in the US, I returned to Maynooth University in Ireland as a Science Foundation Ireland Stokes Lecturer where I established a research group in Soft Matter and Biophysical chemistry. I was promoted to Associate Professor in 2016 and served as Head of Department from 2017 to 2020. I joined the School of Physics at the University of Bristol in 2020.
Research interests
We are interested in how and why proteins, peptides and other macromolecules assemble into condensed phases such as crystals, amorphous aggregates, gels and fibers. We aim to understand how inter-molecular protein-protein interactions relate to the assembly process. We are particularly interested in how anisotropic protein-protein interactions direct protein assembly. We use protein phase diagrams to measure and understand this behaviour. We are also interested in the rational design of protein based materials, in the mechanical properties of protein gels and tissues and in the formulation and stability of proteins.
Current projects include, liquid-liquid phase separation of proteins, membrane protein crystallization, peptide assembly and protein formulation and stability
Projects and supervisions
Research projects
BBSRC International Institutional Award 2022 _ McManus
Principal Investigator
Managing organisational unit
School of PhysicsDates
01/11/2022 to 31/03/2023
8094 RAMP - Marie Curie ITN
Principal Investigator
Managing organisational unit
School of PhysicsDates
01/10/2020 to 31/08/2021
Thesis supervisions
Publications
Recent publications
01/01/2024Assembling membraneless organelles from de novo designed proteins
Nature Chemistry
Maturation and Conformational Switching of a De Novo Designed Phase-Separating Polypeptide
Journal of the American Chemical Society
Polymorphic protein phase transitions driven by surface anisotropy
Journal of Chemical Physics
Design Rules for Antibody Delivery by Self-Assembled Block-Copolyelectrolyte Nanocapsules
Macromolecules
Squaramide-Based Self-Associating Amphiphiles for Anion Recognition
Chempluschem
Teaching
PHYS 31211 Biophysics
PHYSM3100 Student Seminar
PHYSM3406 MSc Research Project